EMP1
EMP1 Gene Summary
Involved in bleb assembly and cell death. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | EMP1 |
| Official Name | epithelial membrane protein 1 [Source:HGNC Symbol;Acc:HGNC:3333] |
| Ensembl ID | ENSG00000134531 |
| Bio databases IDs | |
| Aliases | epithelial membrane protein 1 |
| Synonyms | CL-20,ENP1MR,epithelial membrane protein 1,I-8-09,TMP |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PMP-22/EMP/MP20/Claudin family
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- EGFR
- USP7
- MYC
- PMP22
- EHHADH
- EBP
- ANKS6
- Integrin
- EDA
- CEP70
disease
- epithelial cancer
- epithelial neoplasia
- cancer
- adenoma formation
- metastasis
- glioblastoma cancer
- central nervous system cancer
- head and neck cancer
- head and neck neoplasia
- glioma cancer
regulated by
- beta-estradiol
- lipopolysaccharide
- RAF1
- TNF
- MTA1
- thioacetamide
- TP63
- STAT5A/B
- EGF
- CG
regulates
- caspase 3/7
- AKT
- EGFR
- RAC1
- ERK1/2
- SRC (family)
- NOX4
- CD44
- Collagen type X
- RUNX2
role in cell
- phosphorylation in
- activation in
- apoptosis
- proliferation
- cell death
- survival
- formation
- invasion
- condensation
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the EMP1 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- bleb assembly
- apoptotic process
- epidermis development
CELLULAR COMPONENT
Where in the cell the gene product is active
- membrane
- plasma membrane
MOLECULAR FUNCTION
What the gene product does at the molecular level
- protein binding