TET1
TET1 Gene Summary
DNA methylation is an epigenetic mechanism that is important for controlling gene expression. The protein encoded by this gene is a demethylase that belongs to the TET (ten-eleven translocation) family. Members of the TET protein family play a role in the DNA methylation process and gene activation. [provided by RefSeq, Sep 2015]
Details
| Type | Protein Coding |
| Official Symbol | TET1 |
| Official Name | tet methylcytosine dioxygenase 1 [Source:HGNC Symbol;Acc:HGNC:29484] |
| Ensembl ID | ENSG00000138336 |
| Bio databases IDs | |
| Aliases | tet methylcytosine dioxygenase 1, leukemia-associated protein with a CXXC domain, ten-eleven translocation 1 |
| Synonyms | 2510010B09Rik,AA517754,bA119F7.1,BB001228,CXXC6,D10Ertd17e,LCX,mKIAA1676,tet methylcytosine dioxygenase 1 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- nucleic acid binding
- catalytic domain
- 2-oxoglutarate:oxygen oxidoreductase
- iron ion binding
- enzyme
- protein binding
- sequence-specific DNA binding
- DNA binding
- Oxygenase domain of the 2OGFeDO superfamily
- zinc ion binding
- double-stranded DNA binding
- Tet_JBP
- methyl-CpG binding
- CXXC zinc finger domain
Pathways
Biological processes and signaling networks where the TET1 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- OGT
- DCAF1
- SIN3A
- YWHAH
- SOX2
- TCF7
- ZFP36L2
- DAG1
- SP1
- TDG
disease
- breast cancer
- organismal death
- non-insulin-dependent diabetes mellitus
- acute myeloid leukemia
- liver cancer
- metastasis
- kidney injury
- growth failure
- small cell lung cancer
- open-angle glaucoma
regulated by
- decitabine
- OGT
- ATG7
- SOX2
- prolinedithiocarbamate
- DCK
- hydroquinone
- MEK
- GSK3B
- curcumin
regulates
- reactive oxygen species
- EGFR
- FOS
- ID1
- GLI2
- KHDC3L
- CSNK2B
- TCL1A
- SLC40A1
- MEIS1
role in cell
- expression in
- number
- differentiation
- cell death
- G2/M phase
- response by
- cellular infiltration by
- downregulation in
- hypomethylation in
- binding in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the TET1 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- stem cell maintenance
- protein O-linked glycosylation
- 5-methylcytosine catabolic process
- positive regulation of transcription from RNA polymerase II promoter
- hypomethylation of CpG island
- dendrite morphogenesis
- negative regulation of transcription from RNA polymerase II promoter
- chromatin remodeling
- inner cell mass cell differentiation
- cellular response to reactive oxygen species
- negative regulation of transforming growth factor beta receptor signaling pathway
- negative regulation of cell migration
CELLULAR COMPONENT
Where in the cell the gene product is active
- nucleus
- Sin3-type complex
MOLECULAR FUNCTION
What the gene product does at the molecular level
- DNA binding
- zinc ion binding
- protein binding
- iron ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- methyl-CpG binding
- methylcytosine dioxygenase activity