NTRK3
NTRK3 Gene Summary
This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]
Details
| Type | Protein Coding |
| Official Symbol | NTRK3 |
| Official Name | neurotrophic receptor tyrosine kinase 3 [Source:HGNC Symbol;Acc:HGNC:8033] |
| Ensembl ID | ENSG00000140538 |
| Bio databases IDs | |
| Aliases | neurotrophic receptor tyrosine kinase 3 |
| Synonyms | GP145-TrkC,gp145(trkC),neurotrophic receptor tyrosine kinase 3,neurotrophic tyrosine kinase, receptor, type 3,Ntrk3 tv3,TRKC |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Leucine rich repeat C-terminal motif
- neurotrophin p75 receptor
- Leucine rich repeat
- protein-tyrosine kinase
- Protein kinase domain
- GPI-linked ephrin receptor
- transmembrane receptor protein serine/threonine kinase
- cytoplasmic domain
- Immunoglobulin like
- intracellular domain
- membrane-proximal domain
- Tyrosine kinase, catalytic domain
- growth factor binding
- extracellular domain
- Protein kinase (unclassified specificity)
- Protein tyrosine and serine/threonine kinase
- immunoglobulin domain
- ectodomain
- Immunoglobulin I-set domain
- Leucine rich repeat C-terminal domain
- protein binding
- p53 binding
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- Shc binding site
- Protein Kinases, catalytic domain
- transmembrane domain
- tyrosine kinase domain
Pathways
Biological processes and signaling networks where the NTRK3 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- MINK1
- CALM3
- SFN
- IRS1
- SLC39A11
- SCO2
- DGKE
- NTF3
- CLINT1
- HSPH1
disease
- neoplasia
- abdominal cancer
- cancer
- schizophrenia
- epithelial cancer
- gastrointestinal neoplasia
- metastatic colon cancer
- metastatic rectal cancer
- biliary tract cancer
- advanced rectal cancer
regulated by
- BMS-536924
- AZD-7451
- DNMT1
- NTF3
- ISL1
- BMS355249
- morphine
- beta-estradiol
- CYLD
- HNRNPA2B1
regulates
- SLC2A4
- ERK1/2
- IL11
- SMAD3
- IL1A
- ERK
- YAP/TAZ
- TGFB1
- SNAI2
- AKT1
role in cell
- signaling in
- invasion by
- proliferation
- survival
- invasion
- migration
- expression in
- cell death
- apoptosis
- phosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- detergent resistant lipid raft fraction
- glutaminergic synapse
- Cytoplasm
- cell surface
- intracellular space
- perinuclear region
- postsynaptic region
- cellular membrane
- Nucleus
- cytosol
- apical membrane
- postsynaptic membrane
- basolateral membrane
- Golgi membrane
- mitochondrial outer membrane
- dendrite initial segments
- filopodia
- perikaryon
- axons
- Merkel nerve endings
- sensory axons
- apical processes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the NTRK3 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- positive regulation of MAP kinase activity
- multicellular organismal development
- positive regulation of cell proliferation
- positive regulation of positive chemotaxis
- nervous system development
- transmembrane receptor protein tyrosine kinase signaling pathway
- heart development
- positive regulation of gene expression
- negative regulation of protein phosphorylation
- positive regulation of protein phosphorylation
- positive regulation of ERK1 and ERK2 cascade
- cell differentiation
- positive regulation of kinase activity
- positive regulation of neuron projection development
- positive regulation of protein kinase B signaling cascade
- activation of protein kinase B activity
- positive regulation of peptidyl-serine phosphorylation
- positive regulation of cell migration
CELLULAR COMPONENT
Where in the cell the gene product is active
- receptor complex
- plasma membrane
- axon
MOLECULAR FUNCTION
What the gene product does at the molecular level
- ATP binding
- p53 binding
- protein binding
- transmembrane receptor protein tyrosine kinase activity
- neurotrophin binding
- neurotrophin receptor activity