SLC39A6
SLC39A6 Gene Summary
Zinc is an essential cofactor for hundreds of enzymes. It is involved in protein, nucleic acid, carbohydrate, and lipid metabolism, as well as in the control of gene transcription, growth, development, and differentiation. SLC39A6 belongs to a subfamily of proteins that show structural characteristics of zinc transporters (Taylor and Nicholson, 2003 [PubMed 12659941]).[supplied by OMIM, Mar 2008]
Details
| Type | Protein Coding |
| Official Symbol | SLC39A6 |
| Official Name | solute carrier family 39 member 6 [Source:HGNC Symbol;Acc:HGNC:18607] |
| Ensembl ID | ENSG00000141424 |
| Bio databases IDs | |
| Aliases | solute carrier family 39 member 6 |
| Synonyms | Ermelin,LIV-1,solute carrier family 39 member 6,solute carrier family 39 (metal ion transporter), member 6,ZIP6 |
| Species | Human, homo_sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ZIP Zinc transporter
- protein binding
- zinc ion transporter
- transporter
Pathways
Biological processes and signaling networks where the SLC39A6 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- RNF183
- RAB9A
- BRCA1
- HTR2C
- MCAM
- TNFRSF9
- TGOLN2
- HLA-DRA
- GLP1R
- RAC3
disease
- neoplasia
- psoriasis
- hepatocellular carcinoma
- liver cancer
- epithelial cancer
- breast carcinoma
- mechanical hypersensitivity
regulated by
- trans-hydroxytamoxifen
- lipopolysaccharide
- TCR (complex)
- beta-estradiol
- diazoxide
- 6-formylindolo[3,2-b]carbazole
- D-glucose
- Immunoglobulin
- COP1
- Retromer
regulates
- IFNG
- ERK1/2
- CDH1
- IL2
- CD69
- Zn2+
- proinsulin
- MHC II (complex)
- heavy metal
- SNAI1
role in cell
- expression in
- apoptosis
- proliferation
- activation in
- activation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Nucleus
- Endoplasmic Reticulum
- apical membrane
- membrane rafts
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the SLC39A6 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- zinc ion import
- cellular zinc ion homeostasis
- epithelial to mesenchymal transition
- zinc ion transmembrane transport
- bicarbonate transport
- lymphocyte activation
- cellular cation homeostasis
- T cell receptor signaling pathway
CELLULAR COMPONENT
Where in the cell the gene product is active
- membrane raft
- endoplasmic reticulum
- apical plasma membrane
- plasma membrane
- lamellipodium membrane
- cell surface
MOLECULAR FUNCTION
What the gene product does at the molecular level
- protein binding
- zinc ion transmembrane transporter activity