GRB7
GRB7 Gene Summary
The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with epidermal growth factor receptor (EGFR) and ephrin receptors. The protein plays a role in the integrin signaling pathway and cell migration by binding with focal adhesion kinase (FAK). Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]
Details
| Type | Protein Coding |
| Official Symbol | GRB7 |
| Official Name | growth factor receptor bound protein 7 [Source:HGNC Symbol;Acc:HGNC:4567] |
| Ensembl ID | ENSG00000141738 |
| Bio databases IDs | |
| Aliases | growth factor receptor bound protein 7 |
| Synonyms | growth factor receptor bound protein 7,mKIAA4028 |
| Species | Human, homo_sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase binding
- protein binding
- phosphotyrosine binding domain
- Pleckstrin homology-like domain
- BPS (Between PH and SH2)
- proline rich domain
- identical protein binding
- phosphatidylinositol binding
- ras association domain
- Ubl1_cv_Nsp3_N-like
- PH domain
- Src homology 2 (SH2) domain
- Grb and mig domain
Pathways
Biological processes and signaling networks where the GRB7 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- EGFR
- MTOR
- HAX1
- RPL31
- INSR
- ERBB3
- USP10
- MYD88
- CUL1
- phosphatidylinositol-3-phosphate
disease
- neoplasia
- gastric cancer
- renal clear cell adenocarcinoma
- renal clear cell cancer
- rotator cuff injury
- breast cancer
- organismal death
- tumorigenesis
- ovarian cancer
- HER2 negative hormone receptor negative breast cancer
regulated by
- EGF
- dexamethasone
- beta-estradiol
- MAPK1
- receptor protein tyrosine kinase
- tretinoin
- PTK2
- ESRRA
- IL1B
- FGF2
regulates
- STAT3
- NFkB (complex)
- ERK1/2
- PTK2
- AKT
- ERK
- MTOR
- EIF4EBP1
- UCP1
- agar
role in cell
- expression in
- proliferation
- phosphorylation in
- apoptosis
- growth
- migration
- cell death
- recruitment in
- cell viability
- activation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- focal adhesions
- cytosol
- stress granule
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the GRB7 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- stress granule assembly
- insulin receptor signaling pathway
- epidermal growth factor receptor signaling pathway
- negative regulation of insulin receptor signaling pathway
- negative regulation of translation
- positive regulation of cell migration
CELLULAR COMPONENT
Where in the cell the gene product is active
- cytoplasmic stress granule
- focal adhesion
- cytosol
- cell projection
- plasma membrane
MOLECULAR FUNCTION
What the gene product does at the molecular level
- protein kinase binding
- identical protein binding
- RNA binding
- protein binding
- phosphatidylinositol binding