PRDM15 Gene Summary [Human]
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and promoter-specific chromatin binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II; regulation of signal transduction; and regulation of stem cell division. Located in nuclear body. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Retained Intron |
| Official Symbol | PRDM15 |
| Official Name | PR/SET domain 15 [Source:HGNC Symbol;Acc:HGNC:13999] |
| Ensembl ID | ENSG00000141956 |
| Bio databases IDs | |
| Aliases | PR/SET domain 15 |
| Synonyms | C21orf83,E130018M06Rik,ORF62,PFM15,PR domain containing 15,PR Domain Zinc Finger Protein 15,PR/SET domain 15,Zfp298,ZNF298 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PRDM15 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- transcription regulator
- SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
- nucleic acid binding
- double-stranded DNA binding
- Zinc-finger double domain
- SET domain
- SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily
- chromatin binding
- sequence-specific DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- insomnia
- squamous cell lung cancer
- chronic obstructive pulmonary disease
- pervasive developmental disorder
- lung adenocarcinoma
- lung adenocarcinoma formation
- lung squamous cell carcinoma
- Parkinson disease
regulates
- FGFR4
- DNA promoter
- DNA endogenous promoter
- RNA polymerase II
role in cell
- proliferation
- expression in
- colony formation
- cell division
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PRDM15 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of MAPK cascade
- positive regulation of canonical Wnt receptor signaling pathway
- regulation of stem cell division
- positive regulation of transcription from RNA polymerase II promoter
- methylation
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear body
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- methyltransferase activity