IGFBP3
IGFBP3 Gene Summary
This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | IGFBP3 |
| Official Name | insulin like growth factor binding protein 3 [Source:HGNC Symbol;Acc:HGNC:5472] |
| Ensembl ID | ENSG00000146674 |
| Bio databases IDs | |
| Aliases | insulin like growth factor binding protein 3, growth hormone-dependent binding protein, acid stable subunit of the 140 K IGF complex, binding protein 53, binding protein 29, IGF-binding protein 3 |
| Synonyms | BP-53,IBP-3,IGBP3,IGF binding protein 3,IGFI BP3,IGgfbp3,Insulin-like growth factor-binding protein 3 |
| Species | Human, homo_sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- IGF-binding site
- nuclear localization sequence
- heparin binding domain
- insulin-like growth factor binding
- linker domain
- protein binding
- fibronectin binding
- metal binding domain
- protein tyrosine phosphatase activator
- N-linked glycosylation site
- TY
- Insulin-like growth factor binding protein
- basic domain
Pathways
Biological processes and signaling networks where the IGFBP3 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- BAX
- MYC
- SPP1
- IGF2
- TP53
- RAF1
- KRAS
- RXRA
- PPARA
- IGFALS
disease
- neoplasia
- liver cancer
- epithelial cancer
- hepatocellular carcinoma
- squamous cell cancer of the oral cavity
- squamous cell lung cancer
- head and neck cancer
- lung squamous cell carcinoma
- coronary artery disease
- breast carcinoma
regulated by
- TNF
- EGFR
- lipopolysaccharide
- FAR1
- GW501516
- beta-estradiol
- butyric acid
- SP3
- tetradecanoylphorbol acetate
- AGT
regulates
- TERT
- IL1B
- EGFR
- D-glucose
- NFKBIA
- Ccl3
- p38 MAPK
- CCL5
- TNF
- JNK
role in cell
- expression in
- number
- phosphorylation in
- synthesis in
- quantity
- apoptosis
- cell viability
- migration
- survival
- proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- nuclear fraction
- membrane fraction
- heterochromatin
- Cytoplasm
- cell surface
- intracellular space
- perinuclear region
- Nucleus
- Mitochondria
- endoplasmic reticulum lumen
- endosomal compartment
- alpha granules
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the IGFBP3 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- negative regulation of cell proliferation
- positive regulation of myoblast differentiation
- positive regulation of MAPK cascade
- regulation of insulin-like growth factor receptor signaling pathway
- protein phosphorylation
- positive regulation of insulin-like growth factor receptor signaling pathway
- MAPK cascade
- regulation of glucose metabolic process
- negative regulation of signal transduction
- regulation of cell growth
- negative regulation of protein phosphorylation
- type B pancreatic cell proliferation
- apoptotic process
- positive regulation of apoptotic process
- negative regulation of smooth muscle cell proliferation
- osteoblast differentiation
- negative regulation of smooth muscle cell migration
CELLULAR COMPONENT
Where in the cell the gene product is active
- insulin-like growth factor binding protein complex
- endoplasmic reticulum lumen
- nucleus
- extracellular space
- extracellular region
- insulin-like growth factor ternary complex
MOLECULAR FUNCTION
What the gene product does at the molecular level
- protein tyrosine phosphatase activator activity
- protein binding
- metal ion binding
- fibronectin binding
- insulin-like growth factor binding
- insulin-like growth factor I binding
- insulin-like growth factor II binding