TFF3
TFF3 Gene Summary
Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer and affect healing of the epithelium. This gene is expressed in goblet cells of the intestines and colon. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | TFF3 |
| Official Name | trefoil factor 3 [Source:HGNC Symbol;Acc:HGNC:11757] |
| Ensembl ID | ENSG00000160180 |
| Bio databases IDs | |
| Aliases | trefoil factor 3 |
| Synonyms | ITF,mITF,P1B,P1.b,TFI,TIFF3,trefoil factor 3,trefoil factor 3, intestinal |
| Species | Human, homo_sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- Trefoil
- identical protein binding
Pathways
Biological processes and signaling networks where the TFF3 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- UBQLN2
- AKR1C1
- FCGBP
- LINGO2
- SGTA
- PCBD1
- TFF3
- TCF3
- ZSCAN9
disease
- obesity
- gastric adenocarcinoma
- HER2 negative hormone receptor negative breast cancer
- epithelial thyroid cancer
- diabetes mellitus
- colon cancer
- nodular goiter
- primary ovarian cancer
- papillary thyroid cancer
- prostatic intraepithelial neoplasia
regulated by
- butyric acid
- AHR
- beta-estradiol
- PPARD
- IL4
- IL13
- Caco2 cells
- STAT6
- ATF4
- ARID1A
regulates
- FOS
- RELA
- NFKB1
- VEGF
- AKT
- EGFR
- IL6
- CXCL8
- ERBB2
- CDH1
role in cell
- expression in
- activation in
- phosphorylation in
- apoptosis
- growth
- upregulation in
- number
- production in
- invasion by
- cell death
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cell surface
- Plasma Membrane
- secretory granules
- brush border
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the TFF3 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- regulation of glucose metabolic process
- maintenance of gastrointestinal epithelium
CELLULAR COMPONENT
Where in the cell the gene product is active
- extracellular space
- secretory granule
- extracellular region
MOLECULAR FUNCTION
What the gene product does at the molecular level
- identical protein binding
- protein binding