YES1

YES1 Gene Summary

This gene is the cellular homolog of the Yamaguchi sarcoma virus oncogene. The encoded protein has tyrosine kinase activity and belongs to the src family of proteins. This gene lies in close proximity to thymidylate synthase gene on chromosome 18, and a corresponding pseudogene has been found on chromosome 22. [provided by RefSeq, Jul 2008]

Details

Type
Protein Coding
Official Symbol
YES1
Official Name
YES proto-oncogene 1, Src family tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:12841]
Ensembl ID
ENSG00000176105
Bio databases IDs NCBI: 7525 Ensembl: ENSG00000176105
Aliases YES proto-oncogene 1, Src family tyrosine kinase
Synonyms
c-Yes,HsT441,p60c-yes,P61-YES,Yes,YES proto-oncogene 1, Src family tyrosine kinase
Species
Human, Homo sapiens

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • SH4 domain
  • Protein kinase (unclassified specificity)
  • Protein tyrosine and serine/threonine kinase
  • epidermal growth factor receptor binding
  • enzyme binding
  • non-membrane spanning protein tyrosine kinase
  • phosphotyrosine binding
  • protein binding
  • autophosphorylation site
  • protein-tyrosine kinase
  • Protein kinase domain
  • Src Homology 3 domain superfamily
  • kinase
  • Serine/Threonine protein kinases, catalytic domain
  • Protein Kinases, catalytic domain
  • tyrosine kinase domain
  • ion channel binding
  • Src homology 2 (SH2) domain
  • Tyrosine kinase, catalytic domain

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
  • AR
  • FYN
  • EGFR
  • LAMTOR1
  • YES1
  • SRC
  • SNCA
  • CSF1R
  • LAMP3
  • ASAP2
disease
  • neoplasia
  • epithelial neoplasia
  • cardiovascular disorder
  • acute lymphoblastic lymphoma
  • precursor B-cell acute lymphoblastic leukemia
  • obesity
  • advanced phase chronic myeloid leukemia
  • relapsed B cell acute lymphoblastic leukemia
  • refractory chronic myeloid leukemia in accelerated phase
  • Philadelphia-like B-cell acute lymphoblastic leukemia
regulated by
  • taurolithocholate-3-sulfate
  • CAV1
  • dexamethasone
  • LDL
  • NTF3
  • Ca2+
  • mir-145
  • PDGF (complex)
  • BTK
  • FASLG
regulates
  • FYN
  • AKT
  • JNK
  • SLC2A4
  • PI3K (complex)
  • NFkB (complex)
  • IL6
  • ERK1/2
  • AKT1
  • EGFR
role in cell
  • phosphorylation in
  • expression in
  • activation in
  • apoptosis
  • assembly
  • proliferation
  • transformation
  • cell viability
  • migration
  • formation

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • detergent-insoluble membrane fraction
  • raft fractions
  • membrane fraction
  • detergent resistant lipid raft fraction
  • glutaminergic synapse
  • cell junction
  • organelle
  • Nucleus
  • Plasma Membrane
  • vesicles
  • Golgi Apparatus
  • actin filaments
  • cytosol
  • apical cell surfaces
  • caveolae
  • acrosome
  • synaptosomes
  • zonula adherens
  • lateral cell-cell contacts
  • membrane rafts
  • detergent-soluble fraction
  • cytosolic fraction

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the YES1 gene, providing context for its role in the cell.

BIOLOGICAL PROCESS

Functions and activities the gene product is involved in
  • protein modification process
  • T cell costimulation
  • cellular response to platelet-derived growth factor stimulus
  • transmembrane receptor protein tyrosine kinase signaling pathway
  • regulation of vascular permeability
  • Fc-gamma receptor signaling pathway involved in phagocytosis
  • positive regulation of transcription from RNA polymerase II promoter
  • protein phosphorylation
  • negative regulation of inflammatory response to antigenic stimulus
  • regulation of glucose transport
  • cellular response to transforming growth factor beta stimulus
  • cellular response to retinoic acid
  • innate immune response
  • ephrin receptor signaling pathway
  • cell differentiation
  • leukocyte migration
  • positive regulation of peptidyl-tyrosine phosphorylation

CELLULAR COMPONENT

Where in the cell the gene product is active
  • centrosome
  • extracellular vesicular exosome
  • focal adhesion
  • cytosol
  • Golgi apparatus
  • actin filament
  • plasma membrane

MOLECULAR FUNCTION

What the gene product does at the molecular level
  • phosphotyrosine binding
  • ATP binding
  • protein tyrosine kinase activity
  • protein binding
  • non-membrane spanning protein tyrosine kinase activity
  • ion channel binding
  • receptor binding
  • enzyme binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.