Ptpn6 Gene Summary [Mouse]
Enables several functions, including phosphotyrosine residue binding activity; protein domain specific binding activity; and protein tyrosine phosphatase activity. Involved in several processes, including epididymis development; negative regulation of cytokine production; and negative regulation of inflammatory response to wounding. Acts upstream of or within several processes, including hemopoiesis; negative regulation of protein phosphorylation; and regulation of lymphocyte activation. Located in cell-cell junction. Part of alpha-beta T cell receptor complex. Is active in cytoplasm. Is expressed in several structures, including central nervous system; liver; retina; and thymus primordium. Orthologous to human PTPN6 (protein tyrosine phosphatase non-receptor type 6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ptpn6 |
| Official Name | protein tyrosine phosphatase, non-receptor type 6 [Source:MGI Symbol;Acc:MGI:96055] |
| Ensembl ID | ENSMUSG00000004266 |
| Bio databases IDs | |
| Aliases | protein tyrosine phosphatase, non-receptor type 6 |
| Synonyms | 70Z-SHP, HCP, HCPH, HPTP1C, me, protein tyrosine phosphatase non-receptor type 6, protein tyrosine phosphatase, non-receptor type 6, PTP1, PTP-1C, Ptph6, PTPTY-42, SHP-1, SHP-1L, SH-PTP1, Sr Homology Protein 1 Phosphatase |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ptpn6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase binding
- protein-tyrosine-phoshatase
- catalytic domain
- SH2-domain binding
- cell adhesion molecule binding
- Protein tyrosine phosphatase, catalytic domain
- phosphotyrosine binding
- PTP_DSP_cys
- protein binding
- phosphatase domain
- proline rich domain
- Protein tyrosine phosphatase, catalytic domain motif
- SH3-domain binding
- PTPase domain
- Protein tyrosine phosphatase, catalytic domain, undefined specificity
- Dual specificity phosphatase, catalytic domain
- hematopoietin/interferon-class (D200-domain) cytokine receptor ligand
- Protein-tyrosine phosphatase
- natural killer cell lectin-like receptor binding
- transmembrane receptor protein tyrosine phosphatase
- phosphatase
- active site
- Src homology 2 (SH2) domain
Pathways
Biological processes and signaling networks where the Ptpn6 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Antiproliferative Role of Somatostatin Receptor 2
- B Cell Receptor Signaling
- CD28 Signaling in T Helper Cells
- Chronic Myeloid Leukemia Signaling
- Erythropoietin Signaling
- FGF Signaling
- Growth Hormone Signaling
- IL-3 Signaling
- IL-4 Signaling
- JAK/Stat Signaling
- Melanocyte Development and Pigmentation Signaling
- Natural Killer Cell Signaling
- Production of Nitric Oxide and Reactive Oxygen Species in Macrophages
- Renin-Angiotensin Signaling
- Role of JAK1, JAK2 and TYK2 in Interferon Signaling
- Role of JAK2 in Hormone-like Cytokine Signaling
- STAT3 Pathway
- Systemic Lupus Erythematosus Signaling
- T Cell Receptor Signaling
- VEGF Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- psoriasis
- neoplasia
- familial hemophagocytic lymphohistiocytosis type 2
- natural killer/T-cell lymphoma
- T-cell non-Hodgkin disease
- natural killer cell neoplasia
- chronic inflammatory disorder
- glomerulonephritis
- allergic airway inflammation
- mature T-cell neoplasia
phenotypes
- abnormal CD8-positive alpha beta T cell morphology
- abnormal CD8-positive alpha-beta T cell differentiation
- abnormal CNS glial cell morphology
- abnormal Peyer's patch morphology
- abnormal T cell differentiation
- abnormal T cell physiology
- abnormal astrocyte morphology
- abnormal bone marrow cell physiology
- abnormal cell cycle
- abnormal cell cycle checkpoint function
- abnormal circulating chemokine level
- abnormal circulating serum amyloid protein level
- abnormal coat appearance
- abnormal forebrain morphology
- abnormal granulocyte morphology
- abnormal hippocampus CA1 region morphology
- abnormal hippocampus development
- abnormal humoral immune response
- abnormal immune system cell morphology
- abnormal immunoglobulin level
- abnormal inflammatory response
- abnormal leukocyte cell number
- abnormal lung morphology
- abnormal microglial cell morphology
- abnormal myelination
- abnormal myeloid leukocyte morphology
- abnormal nervous system morphology
- abnormal photoreceptor inner segment morphology
- abnormal photoreceptor outer segment morphology
- abnormal plasma cell morphology
- abnormal pulmonary alveolar system morphology
- abnormal retina morphology
- abnormal secondary ovarian follicle morphology
- abnormal skin condition
- abnormal skin pigmentation
- abnormal telencephalon development
- abnormal thymus development
- abnormal thymus morphology
- absent limbs
- absent skin pigmentation
- autoimmune response
- chronic inflammation
- decreased B cell number
- decreased B-1 B cell number
- decreased B-2 B cell number
- decreased CD4-positive CD25-positive alpha-beta regulatory T cell number
- decreased CD8-positive naive alpha-beta T cell number
- decreased IgD level
- decreased IgM level
- decreased a wave amplitude
- decreased apoptosis
- decreased b wave amplitude
- decreased body size
- decreased body weight
- decreased bone mass
- decreased bone mineral content
- decreased bone mineral density
- decreased brain size
- decreased cellular sensitivity to gamma-irradiation
- decreased immature B cell number
- decreased mature B cell number
- decreased neuron number
- decreased retinal photoreceptor cell number
- decreased susceptibility to bacterial infection
- decreased susceptibility to bacterial infection induced morbidity/mortality
- decreased thymocyte number
- disorganized photoreceptor outer segment
- enlarged spleen
- extremity edema
- female infertility
- focal hair loss
- increased B-1 B cell number
- increased B-1a cell number
- increased B-1b cell number
- increased CD8-positive alpha-beta memory T cell number
- increased IgA level
- increased IgG level
- increased IgM level
- increased anti-chromatin antibody level
- increased autoantibody level
- increased central memory CD8 positive alpha-beta T cell number
- increased circulating interferon-gamma level
- increased circulating interleukin-1 beta level
- increased circulating interleukin-10 level
- increased circulating interleukin-17 level
- increased circulating interleukin-6 level
- increased dendritic cell number
- increased effector memory CD4-positive alpha-beta T cell number
- increased effector memory CD8-positive alpha-beta T cell number
- increased erythroid progenitor cell number
- increased granulocyte number
- increased immunoglobulin level
- increased inflammatory response
- increased leukocyte cell number
- increased macrophage cell number
- increased microglial cell activation
- increased monocyte cell number
- increased neutrophil cell number
- increased plasma cell number
- increased splenocyte proliferation
- interstitial pneumonia
- lung inflammation
- ovary atrophy
- postnatal lethality
- postnatal lethality complete penetrance
- premature death
- preweaning lethality incomplete penetrance
- psoriasis
- respiratory distress
- retinal outer nuclear layer degeneration
- retinal photoreceptor degeneration
- retinal rod cell degeneration
- rheumatoid arthritis
- salivary gland inflammation
- short photoreceptor outer segment
- skin inflammation
- skin lesions
- small thymus
- spontaneous skin ulceration
- thin retinal outer nuclear layer
- thymus atrophy
- ulcerated paws
role in cell
- outgrowth
- growth
- activation in
- degranulation
- expression in
- apoptosis
- maturation
- phosphorylation in
- survival
- quantity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- nuclear fraction
- soluble fraction
- membrane fraction
- secretory granule lumen
- cell surface
- Extracellular Space
- perinuclear region
- organelle lumens
- cellular membrane
- Nucleus
- Plasma Membrane
- intercellular junctions
- cell-cell contacts
- cytosol
- nucleoplasm
- nucleoli
- membrane rafts
- chromatin
- perikaryon
- dendrites
- apical processes
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ptpn6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- peptidyl-tyrosine phosphorylation
- negative regulation of angiogenesis
- negative regulation of MAPK cascade
- negative regulation of cell proliferation
- positive regulation of cell proliferation
- hemopoietic progenitor cell differentiation
- mitotic cell cycle
- MAPK cascade
- cytokine-mediated signaling pathway
- platelet formation
- megakaryocyte development
- positive regulation of cell adhesion mediated by integrin
- peptidyl-tyrosine dephosphorylation
- platelet aggregation
- negative regulation of tumor necrosis factor production
- T cell receptor signaling pathway
- intracellular signal transduction
- B cell receptor signaling pathway
- negative regulation of peptidyl-tyrosine phosphorylation
- T cell costimulation
- G-protein coupled receptor signaling pathway
- protein dephosphorylation
- regulation of B cell differentiation
- regulation of type I interferon-mediated signaling pathway
- regulation of apoptotic process
- natural killer cell mediated cytotoxicity
- regulation of release of sequestered calcium ion into cytosol
- negative regulation of interleukin-6 production
- regulation of ERK1 and ERK2 cascade
- negative regulation of T cell receptor signaling pathway
- negative regulation of T cell proliferation
- negative regulation of humoral immune response mediated by circulating immunoglobulin
- T cell proliferation
- cell differentiation
- regulation of G1/S transition of mitotic cell cycle
- negative regulation of mast cell activation involved in immune response
- positive regulation of protein kinase B signaling cascade
Cellular Component
Where in the cell the gene product is active
- specific granule lumen
- extracellular region
- nucleolus
- alpha-beta T cell receptor complex
- plasma membrane
- nucleoplasm
- nucleus
- cell-cell junction
- extracellular vesicular exosome
- cytoplasm
- membrane
- cytosol
- macromolecular complex
Molecular Function
What the gene product does at the molecular level
- phosphotyrosine binding
- protein kinase binding
- protein binding
- non-membrane spanning protein tyrosine phosphatase activity
- protein tyrosine phosphatase activity
- cell adhesion molecule binding
- transmembrane receptor protein tyrosine phosphatase activity
- SH3 domain binding
- SH2 domain binding