Gcgr Gene Summary [Mouse]
Enables glucagon receptor activity. Involved in several processes, including cellular response to glucagon stimulus; glucose homeostasis; and regulation of glycogen metabolic process. Acts upstream of or within cellular response to starvation and positive regulation of gene expression. Is active in plasma membrane. Is expressed in several structures, including brain; foot mesenchyme; gut; liver; and male reproductive gland or organ. Used to study Mahvash Disease. Human ortholog(s) of this gene implicated in Mahvash Disease and type 2 diabetes mellitus. Orthologous to human GCGR (glucagon receptor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gcgr |
| Official Name | glucagon receptor [Source:MGI Symbol;Acc:MGI:99572] |
| Ensembl ID | ENSMUSG00000025127 |
| Bio databases IDs | |
| Aliases | glucagon receptor |
| Synonyms | GGR, GL-R, glucagon receptor, GR, MVAH |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gcgr often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- Hormone receptor domain
- 7 transmembrane receptor (Secretin family)
- extracellular domain
- intracellular loop
- guanyl-nucleotide exchange factor
- extracellular loop
- glucagon receptor
- seven-transmembrane G protein-coupled receptor superfamily
- polypeptide hormone binding
Pathways
Biological processes and signaling networks where the Gcgr gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hyperplasia
- liver cancer
- epithelial cancer
- epithelial neoplasia
- pancreatic neoplasia
- non-insulin-dependent diabetes mellitus
- diabetes mellitus
- insulin-dependent diabetes mellitus
- adenoma formation
- benign neoplasia
phenotypes
- abnormal eye morphology
- abnormal kidney morphology
- abnormal liver morphology
- enlarged kidney
- female infertility
- increased brain weight
- increased kidney weight
- increased liver weight
- male infertility
- abnormal circulating amino acid level
- abnormal exocrine gland morphology
- abnormal pancreatic acinar cell morphology
- abnormal pancreatic alpha cell differentiation
- abnormal pancreatic alpha cell morphology
- abnormal pancreatic islet morphology
- decreased abdominal adipose tissue amount
- decreased body weight
- decreased brown adipose tissue amount
- decreased carbon dioxide production
- decreased circulating glucose level
- decreased circulating insulin level
- decreased circulating leptin level
- decreased fasting circulating glucose level
- decreased food intake
- decreased gonadal fat pad weight
- decreased interscapular fat pad weight
- decreased litter size
- decreased liver weight
- decreased oxygen consumption
- decreased subcutaneous adipose tissue amount
- decreased susceptibility to diet-induced non-insulin dependent diabetes
- decreased susceptibility to diet-induced obesity
- decreased susceptibility to hepatic steatosis
- decreased susceptibility to weight gain
- decreased total body fat amount
- decreased triglyceride level
- enlarged pancreas
- enlarged pancreatic islets
- hypoactivity
- hypoglycemia
- improved glucose tolerance
- increased bile salt level
- increased body mass index
- increased circulating LDL cholesterol level
- increased circulating glucagon level
- increased glucagon secretion
- increased glucagonoma incidence
- increased insulin sensitivity
- increased pancreas tumor incidence
- increased pancreas weight
- increased pancreatic alpha cell mass
- increased pancreatic alpha cell number
- increased pancreatic alpha cell proliferation
- increased pancreatic beta cell mass
- increased pancreatic beta cell proliferation
- no abnormal phenotype detected
- pancreatic islet hyperplasia
- postnatal lethality incomplete penetrance
- prenatal lethality incomplete penetrance
role in cell
- apoptosis
- binding in
- accumulation in
- proliferation
- cell death
- differentiation
- number
- abnormal morphology
- exocytosis by
- recruitment in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
- endosomes
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gcgr gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- generation of precursor metabolites and energy
- response to starvation
- cell surface receptor signaling pathway
- response to nutrient
- adenylate cyclase-modulating G-protein coupled receptor signaling pathway
- adenylate cyclase-activating G-protein coupled receptor signaling pathway
- cellular response to starvation
- regulation of blood pressure
- exocytosis
- hormone-mediated signaling pathway
- cellular response to glucagon stimulus
- positive regulation of gene expression
- glucose homeostasis
- regulation of glycogen metabolic process
Cellular Component
Where in the cell the gene product is active
- endosome
- membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- glucagon receptor activity
- guanyl-nucleotide exchange factor activity
- peptide hormone binding