Pnpla2 Gene Summary [Mouse]
Enables retinyl-palmitate esterase activity and triacylglycerol lipase activity. Involved in several processes, including acylglycerol metabolic process; negative regulation of triglyceride storage; and positive regulation of triglyceride catabolic process. Acts upstream of or within lipid catabolic process and lipid droplet organization. Located in cytoplasm and lipid droplet. Is active in cytosol. Is expressed in brown fat and heart. Orthologous to human PNPLA2 (patatin like phospholipase domain containing 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pnpla2 |
| Official Name | patatin-like phospholipase domain containing 2 [Source:MGI Symbol;Acc:MGI:1914103] |
| Ensembl ID | ENSMUSG00000025509 |
| Bio databases IDs | |
| Aliases | patatin-like phospholipase domain containing 2 |
| Synonyms | 0610039C21Rik, 1110001C14Rik, Adipose triglyceride lipase, ATGL, DESNUTRIN, FP17548, Gs2, iPLA2zeta, LOC100507839, LOC100911615, patatin-like phospholipase domain containing 2, PEDF-R, RGD1309044, TRIACYLGLYCEROL HYDROLASE, TTS2, TTS-2.2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pnpla2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- acylglycerol O-acyltransferase
- Patatins and Phospholipases
- enzyme
- protein binding
- retinyl-palmitate esterase
- lipoprotein lipase
- transmembrane receptor
- phospholipase A2
- hydrophobic domain
- triacylglycerol lipase
Pathways
Biological processes and signaling networks where the Pnpla2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial cancer
- liver cancer
- hereditary disorder
- Fuchs endothelial dystrophy
- Neutral lipid storage disease with myopathy
- cardiac hypertrophy
- fibrosis
- medulloblastoma SHH subtype
- brain cancer
phenotypes
- abnormal brown adipose tissue morphology
- abnormal cardiomyocyte apoptosis
- abnormal cardiovascular system morphology
- abnormal cardiovascular system physiology
- abnormal circulating glucose level
- abnormal circulating hormone level
- abnormal circulating insulin level
- abnormal enzyme/coenzyme activity
- abnormal gas homeostasis
- abnormal glucose tolerance
- abnormal heart morphology
- abnormal heart ventricle morphology
- abnormal homeostasis
- abnormal lipid homeostasis
- abnormal metabolism
- abnormal mitochondrion morphology
- abnormal myocardial fiber morphology
- abnormal myocardial fiber physiology
- abnormal myocardium layer morphology
- abnormal respiratory quotient
- abnormal white adipose tissue morphology
- cardiac edema
- cardiac fibrosis
- cardiac hypertrophy
- congestive heart failure
- decreased circulating HDL cholesterol level
- decreased circulating VLDL triglyceride level
- decreased circulating free fatty acid level
- decreased circulating glucose level
- decreased circulating insulin level
- decreased circulating triglyceride level
- decreased oxygen consumption
- decreased ventricle muscle contractility
- dilated heart left ventricle
- dilated heart right ventricle
- hepatic steatosis
- impaired adaptive thermogenesis
- impaired lipolysis
- improved glucose tolerance
- increased body mass index
- increased body weight
- increased brown adipose tissue amount
- increased cardiac muscle glycogen level
- increased circulating leptin level
- increased fatty acid level
- increased gonadal fat pad weight
- increased heart rate
- increased heart weight
- increased inguinal fat pad weight
- increased insulin sensitivity
- increased interscapular fat pad weight
- increased left ventricle weight
- increased liver triglyceride level
- increased respiratory quotient
- increased triglyceride level
- increased white adipose tissue amount
- premature death
- pulmonary vascular congestion
- thick interventricular septum
role in cell
- production in
- expression in
- apoptosis
- phosphorylation in
- cell death
- uptake in
- quantity
- activation in
- growth
- proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Plasma Membrane
- Endoplasmic Reticulum
- lipid droplets
- cytosol
- endoplasmic reticulum membrane
- endoplasmic reticulum lumen
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pnpla2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- acylglycerol acyl-chain remodeling
- negative regulation of sequestering of triglyceride
- lipid storage
- lipid homeostasis
- diacylglycerol biosynthetic process
- retinol metabolic process
- positive regulation of triglyceride catabolic process
- triglyceride catabolic process
- cellular triglyceride homeostasis
Cellular Component
Where in the cell the gene product is active
- lipid particle
- endoplasmic reticulum membrane
- endoplasmic reticulum lumen
- cytoplasm
- membrane
- cytosol
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- phospholipase A2 activity
- protein binding
- mono-olein transacylation activity
- diolein transacylation activity
- retinyl-palmitate esterase activity
- triglyceride lipase activity
- lipoprotein lipase activity
- acylglycerol O-acyltransferase activity