Safb Gene Summary [Mouse]
Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and chromatin binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within estrogen receptor signaling pathway; hormone metabolic process; and regulation of growth. Predicted to be located in midbody and nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; future brain; olfactory epithelium; reproductive system; and retina layer. Orthologous to human SAFB (scaffold attachment factor B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Safb |
| Official Name | scaffold attachment factor B [Source:MGI Symbol;Acc:MGI:2146974] |
| Ensembl ID | ENSMUSG00000071054 |
| Bio databases IDs | |
| Aliases | scaffold attachment factor B |
| Synonyms | 3110021E02Rik, 5330423C17Rik, AU018122, D18386, E130307D12, HAP, HET, SAF-B1, Scaffold Attachment Factor B |
| Species | Mouse, Mus musculus |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Safb often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA recognition motif (RRM) superfamily
- SAP motif
- RNA recognition motif
- double-stranded DNA binding
- nucleic acid binding
- SAP domain
- chromatin binding
- protein binding
- sequence-specific DNA binding
Pathways
Biological processes and signaling networks where the Safb gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cyanosis
- hyperplasia
- azoospermia
phenotypes
- Leydig cell hyperplasia
- abnormal branching involved in seminal vesicle morphogenesis
- abnormal erythropoiesis
- abnormal female reproductive system morphology
- abnormal fertility/fecundity
- abnormal gametogenesis
- abnormal liver morphology
- abnormal lung alveolus development
- abnormal male germ cell apoptosis
- abnormal male reproductive system morphology
- abnormal oviduct transport
- abnormal sex gland physiology
- absent gastric milk in neonates
- arrest of spermatogenesis
- azoospermia
- cyanosis
- decreased body size
- decreased body weight
- decreased circulating estradiol level
- decreased circulating insulin-like growth factor I level
- decreased circulating testosterone level
- decreased fetal size
- decreased litter size
- decreased male germ cell number
- decreased testis weight
- embryonic lethality during organogenesis incomplete penetrance
- impaired ovarian folliculogenesis
- male infertility
- neonatal lethality complete penetrance
- ovary atrophy
- oviduct atrophy
- prenatal lethality incomplete penetrance
- reduced female fertility
- reduced male mating frequency
- seminiferous tubule degeneration
- small oviduct
- small seminal vesicle
- small thoracic cage
role in cell
- apoptosis
- growth
- cell focus formation
- immortalization
- contact growth inhibition
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- midbody
- nucleoplasm
- interchromatin granule clusters