LXR/RXR Activation
The retinoid X receptors (RXRs) are nuclear receptors that mediate the biological effects of retinoids by their involvement in retinoic acid-mediated gene activation. RXRα is the dimerization partner for the type II nuclear receptors that includes the liver X receptor (LXR). The LXR receptor is activated by oxysterol ligands and forms a heterodimer with RXR. After heterodimerization LXR initiates transcription of target genes by binding to the LXR response element. LXR/RXR is involved in the regulation of lipid metabolism, inflammation, and cholesterol to bile acid catabolism...
Pathway Summary
The retinoid X receptors (RXRs) are nuclear receptors that mediate the biological effects of retinoids by their involvement in retinoic acid-mediated gene activation. RXRα is the dimerization partner for the type II nuclear receptors that includes the liver X receptor (LXR). The LXR receptor is activated by oxysterol ligands and forms a heterodimer with RXR. After heterodimerization LXR initiates transcription of target genes by binding to the LXR response element. LXR/RXR is involved in the regulation of lipid metabolism, inflammation, and cholesterol to bile acid catabolism. Genes regulated by LXR include the ATP-binding cassette transporter A1 (ABCA1), which effluxes cholesterol from extrahepatic cells, the sterol regulatory element binding protein-1c (SREBP-1c), AIM and LPL.
LXR/RXR Activation Genes list
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A1BGalpha-1-B glycoprotein ABCA1ATP binding cassette subfamily A member 1 ABCG1ATP binding cassette subfamily G member 1 ABCG4ATP binding cassette subfamily G member 4 ABCG5ATP binding cassette subfamily G member 5 ABCG8ATP binding cassette subfamily G member 8 ACACAacetyl-CoA carboxylase alpha AGTangiotensinogen AHSGalpha 2-HS glycoprotein ALBalbumin AMBPalpha-1-microglobulin/bikunin precursor APOA1apolipoprotein A1 APOA2apolipoprotein A2 APOA4apolipoprotein A4 APOA5apolipoprotein A5 APOBapolipoprotein B APOC1apolipoprotein C1 APOC2apolipoprotein C2 APOC3apolipoprotein C3 APOC4apolipoprotein C4 APODapolipoprotein D APOEapolipoprotein E APOFapolipoprotein F APOHapolipoprotein H APOL1apolipoprotein L1 APOMapolipoprotein M ARG2arginase 2 C3complement C3 C9complement C9 CCL2C-C motif chemokine ligand 2 CCL7C-C motif chemokine ligand 7 CD14CD14 molecule CD36CD36 molecule CETPcholesteryl ester transfer protein CLUclusterin CYP51A1cytochrome P450 family 51 subfamily A member 1 CYP7A1cytochrome P450 family 7 subfamily A member 1 ECHS1enoyl-CoA hydratase, short chain 1 FASNfatty acid synthase FDFT1farnesyl-diphosphate farnesyltransferase 1 FGAfibrinogen alpha chain GCGC vitamin D binding protein HADHhydroxyacyl-CoA dehydrogenase HMGCR3-hydroxy-3-methylglutaryl-CoA reductase HPRhaptoglobin-related protein HPXhemopexin IL18interleukin 18 IL18RAPinterleukin 18 receptor accessory protein IL1Ainterleukin 1 alpha IL1Binterleukin 1 beta IL1F10interleukin 1 family member 10 IL1R1interleukin 1 receptor type 1 IL1R2interleukin 1 receptor type 2 IL1RAPinterleukin 1 receptor accessory protein IL1RAPL1interleukin 1 receptor accessory protein like 1 IL1RAPL2interleukin 1 receptor accessory protein like 2 IL1RL1interleukin 1 receptor like 1 IL1RL2interleukin 1 receptor like 2 IL1RNinterleukin 1 receptor antagonist IL33interleukin 33 IL36Ainterleukin 36 alpha IL36Binterleukin 36 beta IL36Ginterleukin 36 gamma IL36RNinterleukin 36 receptor antagonist IL37interleukin 37 IL6interleukin 6 IRF3interferon regulatory factor 3 ITIH4inter-alpha-trypsin inhibitor heavy chain 4 KNG1kininogen 1 LBPlipopolysaccharide binding protein LCATlecithin-cholesterol acyltransferase LDLRlow density lipoprotein receptor LPAlipoprotein(a) LPLlipoprotein lipase LY96lymphocyte antigen 96 LYZlysozyme MLXIPLMLX interacting protein like MMP9matrix metallopeptidase 9 MSR1macrophage scavenger receptor 1 MYLIPmyosin regulatory light chain interacting protein NCOR1nuclear receptor corepressor 1 NCOR2nuclear receptor corepressor 2 NFKB1nuclear factor kappa B subunit 1 NFKB2nuclear factor kappa B subunit 2 NGFRnerve growth factor receptor NOS2nitric oxide synthase 2 NR1H2nuclear receptor subfamily 1 group H member 2 NR1H3nuclear receptor subfamily 1 group H member 3 NR1H4nuclear receptor subfamily 1 group H member 4 ORM1orosomucoid 1 ORM2orosomucoid 2 PCYOX1prenylcysteine oxidase 1 PLTPphospholipid transfer protein PON1paraoxonase 1 PON3paraoxonase 3 PTGS2prostaglandin-endoperoxide synthase 2 RBP4retinol binding protein 4 RELREL proto-oncogene, NF-kB subunit RELARELA proto-oncogene, NF-kB subunit RELBRELB proto-oncogene, NF-kB subunit RXRAretinoid X receptor alpha RXRBretinoid X receptor beta RXRGretinoid X receptor gamma S100A8S100 calcium binding protein A8 SAA1serum amyloid A1 SAA2serum amyloid A2 SAA4serum amyloid A4, constitutive SERPINA1serpin family A member 1 SERPINF1serpin family F member 1 SERPINF2serpin family F member 2 TFtransferrin TLR3toll like receptor 3 TLR4toll like receptor 4 TNFtumor necrosis factor TNFRSF11BTNF receptor superfamily member 11b TNFRSF1ATNF receptor superfamily member 1A TNFRSF1BTNF receptor superfamily member 1B TTRtransthyretin UGT1A3UDP glucuronosyltransferase family 1 member A3 VTNvitronectin
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