Target List
Insulin Receptor-Associated Proteins
Insulin & Receptors
INS, INSL3, IRS1, IRS2, IRS4, SORBS1
Insulin-Like Growth Factors & Receptors
IGF1R, IGF2, IGFBP1
SH3 / SH2 Adaptor Proteins
CBL, GAB1, GRB2, IRS4, NCK1
Other Insulin Receptor-Associated Proteins
CAP1, DOK1, DOK2, DOK3, FRS2, FRS3, INSR, PDPK1, PPP1CA, PTPN1 (PTP1B), PTPRF, SHC1
PI3 Kinase Signaling
PI3 Kinase Canoncial Pathway Genes
AKT1, AKT2, AKT3, EIF2B1, EIF4EBP1 (4E-BP1), GSK3A, GSK3B, MTOR, PDPK1, PIK3CA (p110-alpha), PIK3R1 (p85-ALPHA), PIK3R2 (p85-BETA), PRKCG, PRKCI, PRKCZ
PI3 Kinase Signaling Target Genes
BCL2L1 (BCLXL), BCL2L1 (BCLXL), BCL2L1 (BCLXL), DUSP14, G6PC, HK2, IGFBP1, PCK2, SERPINE1 (PAI-1), SLC2A4 (GLUT4), SREBF1, UCP1, VEGFA
MAP Kinase Signaling
MAP Kinase Canoncial Pathway Genes
ARAF, BRAF, EIF2B1, GRB2, HRAS, MAP2K1, MAPK1 (ERK2), RAF1, RPS6KA1, RRAS, RRAS2, SHC1, SOS1
MAP Kinase Signaling Target Genes
ANG, BCL2L1 (BCLXL), BCL2L1 (BCLXL), BCL2L1 (BCLXL), ERCC1, FOS, LDLR, NOS2 (iNOS), UCP1
Primary Insulin Signaling Target Genes
CEBPA, CEBPB, FOS, JUN, LEP (Leptin), PRL
Secondary Insulin Signaling Effector Target Genes
NPY, PCK2, SLC2A1, SLC2A4 (GLUT4), TG
PPARγ Targets
ACOX1, ADRB3, AEBP1, CAP1, CEBPA, CEBPB, PCK2, PPARG, RETN
SREBP1 Targets
ACACA, FBP1, G6PC, GCK, PCK2, PKM
Carbohydrate Metabolism
Glucose Metabolism
FBP1, G6PC, GCK, HK2, INS, IRS2, PCK2, PKM, SLC2A1, SLC2A4 (GLUT4), SORBS1
Glycogen Metabolism
G6PC, GSK3B, PPP1CA
Other Carbohydrate Metabolism Genes
ADRB3, GPD1, INSR
Lipid Metabolism
Cholesterol Metabolism
LDLR, SREBF1
Fatty Acid Metabolism
ACACA, ACOX1, FASN
Lipid Transport
LDLR, SORBS1
Other Lipid Metabolism Genes
ARAF, BRAF, INS, LEP (Leptin), PPARG, PRKCG, PRKCI, PRKCZ, RAF1, SHC1
Protein Metabolism
Protein Phosphatases
DUSP14, PPP1CA, PTPN1 (PTP1B), PTPRF
Protein Kinases
AKT1, AKT2, AKT3, ARAF, BRAF, GSK3A, GSK3B, IGF1R, INSL3, INSR, MAP2K1, MAPK1 (ERK2), PDPK1, PRKCG, PRKCI, PRKCZ, RAF1, RPS6KA1
Protein Biosynthesis
ANG, EIF2B1, EIF4EBP1 (4E-BP1), LDLR, PPP1CA
Protein Transport
PRKCI, RRAS2
Other Protein Metabolism Genes
AEBP1, CBL, DOK1, DOK2, FRS2, GAB1, IRS1, NOS2 (iNOS), SORBS1, VEGFA
Transcription Factors & Regulators
Transcriptional Regulation
CEBPA, CEBPB, FOS, JUN, PPARG, SREBF1
Transcription Factors
AEBP1, CBL, CEBPA, CEBPB, FOS, JUN, PPARG, SREBF1
Cell Growth & Differentiation
Cell Cycle
HK2, HRAS, IGF1R, IGF2, KRAS, MAPK1 (ERK2), MTOR, VEGFA
Cell Proliferation
GAB1, IGF1R, IGF2, IRS2, NCK1, NPY, PRL, RAF1, SHC1, VEGFA
Growth Factors & Receptors
GAB1, GRB2, IGF1R, IGF2, IGFBP1, INSR, SHC1, VEGFA
Cell Differentiation
NOS2 (iNOS), PPARG