IL-4 Signaling
Interleukin 4 (IL-4) is a cytokine associated with allergy and asthma. The classical IL-4R is predominantly expressed in hematopoietic cells and consists of IL-4Rα and IL-2Rγc. The alternative form of IL-4R is predominantly expressed in non-hematopoietic cells and consists of IL-4R and IL-13Ralpha chains.IL-4 binding to its receptor activates JAK/TYK2 followed by phosphorylation and dimerization of STAT6. The transcriptional regulator STAT6 is able to induce various genes that are involved immune function like IgE and MHC-II...
Pathway Summary
Interleukin 4 (IL-4) is a cytokine associated with allergy and asthma. The classical IL-4R is predominantly expressed in hematopoietic cells and consists of IL-4Rα and IL-2Rγc. The alternative form of IL-4R is predominantly expressed in non-hematopoietic cells and consists of IL-4R and IL-13Ralpha chains.IL-4 binding to its receptor activates JAK/TYK2 followed by phosphorylation and dimerization of STAT6. The transcriptional regulator STAT6 is able to induce various genes that are involved immune function like IgE and MHC-II. IL-4 induced STAT-6 function can be inhibited by corticosteroids while JAK1 is strongly inhibited by SOCS-1. An alternate pathway involves the IL-4R mediated tyrosyl phosphorylation of IRS-1 followed by activation of the PI3K/AKT/mTOR/p70RSK pathway.
IL-4 Signaling Genes list
Explore Genes related to IL-4 Signaling
AHRaryl hydrocarbon receptor AKT1AKT serine/threonine kinase 1 AKT1S1AKT1 substrate 1 AKT2AKT serine/threonine kinase 2 AKT3AKT serine/threonine kinase 3 ALOX15arachidonate 15-lipoxygenase ALOX15Barachidonate 15-lipoxygenase type B ANO1anoctamin 1 ARG1arginase 1 ATF2activating transcription factor 2 ATF4activating transcription factor 4 BATFbasic leucine zipper ATF-like transcription factor CCL11C-C motif chemokine ligand 11 CCL22C-C motif chemokine ligand 22 CD247CD247 molecule CD3DCD3d molecule CD3ECD3e molecule CD3GCD3g molecule CERT1ceramide transporter 1 COL10A1collagen type X alpha 1 chain COL11A1collagen type XI alpha 1 chain COL11A2collagen type XI alpha 2 chain COL12A1collagen type XII alpha 1 chain COL13A1collagen type XIII alpha 1 chain COL15A1collagen type XV alpha 1 chain COL16A1collagen type XVI alpha 1 chain COL17A1collagen type XVII alpha 1 chain COL18A1collagen type XVIII alpha 1 chain COL19A1collagen type XIX alpha 1 chain COL1A1collagen type I alpha 1 chain COL1A2collagen type I alpha 2 chain COL20A1collagen type XX alpha 1 chain COL21A1collagen type XXI alpha 1 chain COL22A1collagen type XXII alpha 1 chain COL23A1collagen type XXIII alpha 1 chain COL24A1collagen type XXIV alpha 1 chain COL25A1collagen type XXV alpha 1 chain COL26A1collagen type XXVI alpha 1 chain COL27A1collagen type XXVII alpha 1 chain COL28A1collagen type XXVIII alpha 1 chain COL2A1collagen type II alpha 1 chain COL3A1collagen type III alpha 1 chain COL4A1collagen type IV alpha 1 chain COL4A2collagen type IV alpha 2 chain COL4A3collagen type IV alpha 3 chain COL4A4collagen type IV alpha 4 chain COL4A5collagen type IV alpha 5 chain COL4A6collagen type IV alpha 6 chain COL5A1collagen type V alpha 1 chain COL5A2collagen type V alpha 2 chain COL5A3collagen type V alpha 3 chain COL6A1collagen type VI alpha 1 chain COL6A2collagen type VI alpha 2 chain COL6A3collagen type VI alpha 3 chain COL6A5collagen type VI alpha 5 chain COL6A6collagen type VI alpha 6 chain COL7A1collagen type VII alpha 1 chain COL8A1collagen type VIII alpha 1 chain COL8A2collagen type VIII alpha 2 chain COL9A1collagen type IX alpha 1 chain COL9A2collagen type IX alpha 2 chain COL9A3collagen type IX alpha 3 chain CREB1cAMP responsive element binding protein 1 CREB3cAMP responsive element binding protein 3 CREB3L1cAMP responsive element binding protein 3 like 1 CREB3L2cAMP responsive element binding protein 3 like 2 CREB3L3cAMP responsive element binding protein 3 like 3 CREB3L4cAMP responsive element binding protein 3 like 4 CREB5cAMP responsive element binding protein 5 CREBBPCREB binding protein EIF4EBP1eukaryotic translation initiation factor 4E binding protein 1 ERASES cell expressed Ras FASFas cell surface death receptor FCER1GFc fragment of IgE receptor Ig FCER2Fc fragment of IgE receptor II GAB1GRB2 associated binding protein 1 GATA3GATA binding protein 3 GFI1growth factor independent 1 transcriptional repressor GNAI1G protein subunit alpha i1 GNAI2G protein subunit alpha i2 GNAI3G protein subunit alpha i3 GNB1LG protein subunit beta 1 like GRB2growth factor receptor bound protein 2 HLA-DMAmajor histocompatibility complex, class II, DM alpha HLA-DMBmajor histocompatibility complex, class II, DM beta HLA-DOAmajor histocompatibility complex, class II, DO alpha HLA-DOBmajor histocompatibility complex, class II, DO beta HLA-DPA1major histocompatibility complex, class II, DP alpha 1 HLA-DPB1major histocompatibility complex, class II, DP beta 1 HLA-DQA1major histocompatibility complex, class II, DQ alpha 1 HLA-DQA2major histocompatibility complex, class II, DQ alpha 2 HLA-DQB1major histocompatibility complex, class II, DQ beta 1 HLA-DQB2major histocompatibility complex, class II, DQ beta 2 HLA-DQB3major histocompatibility complex, class II, DQ beta 3 HLA-DRAmajor histocompatibility complex, class II, DR alpha HLA-DRB1major histocompatibility complex, class II, DR beta 1 HLA-DRB3major histocompatibility complex, class II, DR beta 3 HLA-DRB4major histocompatibility complex, class II, DR beta 4 HLA-DRB5major histocompatibility complex, class II, DR beta 5 HRASHRas proto-oncogene, GTPase IGHEimmunoglobulin heavy constant epsilon IL13RA1interleukin 13 receptor subunit alpha 1 IL2RGinterleukin 2 receptor subunit gamma IL4interleukin 4 IL4Rinterleukin 4 receptor IRF4interferon regulatory factor 4 IRS1insulin receptor substrate 1 IRS2insulin receptor substrate 2 JAK1Janus kinase 1 JAK3Janus kinase 3 KRASKRAS proto-oncogene, GTPase MAFMAF bZIP transcription factor MAOAmonoamine oxidase A MAPK1mitogen-activated protein kinase 1 MAPK11mitogen-activated protein kinase 11 MAPK12mitogen-activated protein kinase 12 MAPK13mitogen-activated protein kinase 13 MAPK14mitogen-activated protein kinase 14 MAPK3mitogen-activated protein kinase 3 MAPKAP1MAPK associated protein 1 MLST8MTOR associated protein, LST8 homolog MMP12matrix metallopeptidase 12 MRASmuscle RAS oncogene homolog MTORmechanistic target of rapamycin kinase MUC5ACmucin 5AC, oligomeric mucus/gel-forming NFATC2nuclear factor of activated T cells 2 NFIL3nuclear factor, interleukin 3 regulated NFKB1nuclear factor kappa B subunit 1 NFKB2nuclear factor kappa B subunit 2 NR3C1nuclear receptor subfamily 3 group C member 1 NRASNRAS proto-oncogene, GTPase OPN1SWopsin 1, short wave sensitive PIK3C2Aphosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha PIK3C2Bphosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta PIK3C2Gphosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma PIK3C3phosphatidylinositol 3-kinase catalytic subunit type 3 PIK3CAphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha PIK3CBphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta PIK3CDphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta PIK3CGphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma PIK3R1phosphoinositide-3-kinase regulatory subunit 1 PIK3R2phosphoinositide-3-kinase regulatory subunit 2 PIK3R3phosphoinositide-3-kinase regulatory subunit 3 PIK3R4phosphoinositide-3-kinase regulatory subunit 4 PIK3R5phosphoinositide-3-kinase regulatory subunit 5 PIK3R6phosphoinositide-3-kinase regulatory subunit 6 PRR5proline rich 5 PRR5Lproline rich 5 like PTGDR2prostaglandin D2 receptor 2 PTPN6protein tyrosine phosphatase non-receptor type 6 RALARAS like proto-oncogene A RALBRAS like proto-oncogene B RAP1ARAP1A, member of RAS oncogene family RAP1BRAP1B, member of RAS oncogene family RAP2ARAP2A, member of RAS oncogene family RAP2BRAP2B, member of RAS oncogene family RASD1ras related dexamethasone induced 1 RASD2RASD family member 2 RICTORRPTOR independent companion of MTOR complex 2 RPS6KA1ribosomal protein S6 kinase A1 RPS6KB1ribosomal protein S6 kinase B1 RPS6KB2ribosomal protein S6 kinase B2 RPTORregulatory associated protein of MTOR complex 1 RRASRAS related RRAS2RAS related 2 SOCS1suppressor of cytokine signaling 1 SOS1SOS Ras/Rac guanine nucleotide exchange factor 1 SOS2SOS Ras/Rho guanine nucleotide exchange factor 2 STAT3signal transducer and activator of transcription 3 STAT6signal transducer and activator of transcription 6 TGFB1transforming growth factor beta 1 TGFB2transforming growth factor beta 2 TGFB3transforming growth factor beta 3 TGM2transglutaminase 2 TIMP3TIMP metallopeptidase inhibitor 3 TRACT cell receptor alpha constant TRAJ1T cell receptor alpha joining 1 (non-functional) TRAJ10T cell receptor alpha joining 10 TRAJ11T cell receptor alpha joining 11 TRAJ12T cell receptor alpha joining 12 TRAJ13T cell receptor alpha joining 13 TRAJ14T cell receptor alpha joining 14 TRAJ16T cell receptor alpha joining 16 TRAJ17T cell receptor alpha joining 17 TRAJ18T cell receptor alpha joining 18 TRAJ19T cell receptor alpha joining 19 (non-functional) TRAJ2T cell receptor alpha joining 2 (non-functional) TRAJ20T cell receptor alpha joining 20 TRAJ21T cell receptor alpha joining 21 TRAJ22T cell receptor alpha joining 22 TRAJ23T cell receptor alpha joining 23 TRAJ24T cell receptor alpha joining 24 TRAJ25T cell receptor alpha joining 25 (non-functional) TRAJ26T cell receptor alpha joining 26 TRAJ27T cell receptor alpha joining 27 TRAJ28T cell receptor alpha joining 28 TRAJ29T cell receptor alpha joining 29 TRAJ3T cell receptor alpha joining 3 TRAJ30T cell receptor alpha joining 30 TRAJ31T cell receptor alpha joining 31 TRAJ32T cell receptor alpha joining 32 TRAJ33T cell receptor alpha joining 33 TRAJ34T cell receptor alpha joining 34 TRAJ35T cell receptor alpha joining 35 (non-functional) TRAJ36T cell receptor alpha joining 36 TRAJ37T cell receptor alpha joining 37 TRAJ38T cell receptor alpha joining 38 TRAJ39T cell receptor alpha joining 39 TRAJ4T cell receptor alpha joining 4 TRAJ40T cell receptor alpha joining 40 TRAJ41T cell receptor alpha joining 41 TRAJ42T cell receptor alpha joining 42 TRAJ43T cell receptor alpha joining 43 TRAJ44T cell receptor alpha joining 44 TRAJ45T cell receptor alpha joining 45 TRAJ46T cell receptor alpha joining 46 TRAJ47T cell receptor alpha joining 47 TRAJ48T cell receptor alpha joining 48 TRAJ49T cell receptor alpha joining 49 TRAJ5T cell receptor alpha joining 5 TRAJ50T cell receptor alpha joining 50 TRAJ52T cell receptor alpha joining 52 TRAJ53T cell receptor alpha joining 53 TRAJ54T cell receptor alpha joining 54 TRAJ56T cell receptor alpha joining 56 TRAJ57T cell receptor alpha joining 57 TRAJ58T cell receptor alpha joining 58 (non-functional) TRAJ59T cell receptor alpha joining 59 (non-functional) TRAJ6T cell receptor alpha joining 6 TRAJ61T cell receptor alpha joining 61 (non-functional) TRAJ7T cell receptor alpha joining 7 TRAJ9T cell receptor alpha joining 9 TRAV1-1T cell receptor alpha variable 1-1 TRAV1-2T cell receptor alpha variable 1-2 TRAV10T cell receptor alpha variable 10 TRAV11T cell receptor alpha variable 11 (pseudogene) TRAV12-1T cell receptor alpha variable 12-1 TRAV12-2T cell receptor alpha variable 12-2 TRAV12-3T cell receptor alpha variable 12-3 TRAV13-1T cell receptor alpha variable 13-1 TRAV13-2T cell receptor alpha variable 13-2 TRAV14DV4T cell receptor alpha variable 14/delta variable 4 TRAV16T cell receptor alpha variable 16 TRAV17T cell receptor alpha variable 17 TRAV18T cell receptor alpha variable 18 TRAV19T cell receptor alpha variable 19 TRAV2T cell receptor alpha variable 2 TRAV20T cell receptor alpha variable 20 TRAV21T cell receptor alpha variable 21 TRAV22T cell receptor alpha variable 22 TRAV23DV6T cell receptor alpha variable 23/delta variable 6 TRAV24T cell receptor alpha variable 24 TRAV25T cell receptor alpha variable 25 TRAV26-1T cell receptor alpha variable 26-1 TRAV26-2T cell receptor alpha variable 26-2 TRAV27T cell receptor alpha variable 27 TRAV29DV5T cell receptor alpha variable 29/delta variable 5 TRAV3T cell receptor alpha variable 3 TRAV30T cell receptor alpha variable 30 TRAV34T cell receptor alpha variable 34 TRAV36DV7T cell receptor alpha variable 36/delta variable 7 TRAV38-1T cell receptor alpha variable 38-1 TRAV38-2DV8T cell receptor alpha variable 38-2/delta variable 8 TRAV39T cell receptor alpha variable 39 TRAV4T cell receptor alpha variable 4 TRAV40T cell receptor alpha variable 40 TRAV41T cell receptor alpha variable 41 TRAV5T cell receptor alpha variable 5 TRAV6T cell receptor alpha variable 6 TRAV7T cell receptor alpha variable 7 TRAV8-1T cell receptor alpha variable 8-1 TRAV8-2T cell receptor alpha variable 8-2 TRAV8-3T cell receptor alpha variable 8-3 TRAV8-4T cell receptor alpha variable 8-4 TRAV8-6T cell receptor alpha variable 8-6 TRAV8-7T cell receptor alpha variable 8-7 (pseudogene) TRAV9-1T cell receptor alpha variable 9-1 TRAV9-2T cell receptor alpha variable 9-2 TRBC1T cell receptor beta constant 1 TRBC2T cell receptor beta constant 2 TRBD1T cell receptor beta diversity 1 TRBJ1-1T cell receptor beta joining 1-1 TRBJ1-2T cell receptor beta joining 1-2 TRBJ1-3T cell receptor beta joining 1-3 TRBJ1-4T cell receptor beta joining 1-4 TRBJ1-5T cell receptor beta joining 1-5 TRBJ1-6T cell receptor beta joining 1-6 TRBJ2-1T cell receptor beta joining 2-1 TRBJ2-2T cell receptor beta joining 2-2 TRBJ2-2PT cell receptor beta joining 2-2P (non-functional) TRBJ2-3T cell receptor beta joining 2-3 TRBJ2-4T cell receptor beta joining 2-4 TRBJ2-5T cell receptor beta joining 2-5 TRBJ2-6T cell receptor beta joining 2-6 TRBJ2-7T cell receptor beta joining 2-7 TRBV1T cell receptor beta variable 1 (pseudogene) TRBV10-1T cell receptor beta variable 10-1 TRBV10-2T cell receptor beta variable 10-2 TRBV10-3T cell receptor beta variable 10-3 TRBV11-1T cell receptor beta variable 11-1 TRBV11-3T cell receptor beta variable 11-3 TRBV12-1T cell receptor beta variable 12-1 (pseudogene) TRBV12-2T cell receptor beta variable 12-2 (pseudogene) TRBV12-3T cell receptor beta variable 12-3 TRBV12-4T cell receptor beta variable 12-4 TRBV12-5T cell receptor beta variable 12-5 TRBV13T cell receptor beta variable 13 TRBV14T cell receptor beta variable 14 TRBV15T cell receptor beta variable 15 TRBV16T cell receptor beta variable 16 TRBV17T cell receptor beta variable 17 (non-functional) TRBV18T cell receptor beta variable 18 TRBV19T cell receptor beta variable 19 TRBV2T cell receptor beta variable 2 TRBV20-1T cell receptor beta variable 20-1 TRBV23-1T cell receptor beta variable 23-1 (non-functional) TRBV24-1T cell receptor beta variable 24-1 TRBV25-1T cell receptor beta variable 25-1 TRBV26T cell receptor beta variable 26 (pseudogene) TRBV27T cell receptor beta variable 27 TRBV28T cell receptor beta variable 28 TRBV29-1T cell receptor beta variable 29-1 TRBV3-1T cell receptor beta variable 3-1 TRBV30T cell receptor beta variable 30 TRBV4-1T cell receptor beta variable 4-1 TRBV4-2T cell receptor beta variable 4-2 TRBV5-1T cell receptor beta variable 5-1 TRBV5-3T cell receptor beta variable 5-3 (non-functional) TRBV5-4T cell receptor beta variable 5-4 TRBV5-5T cell receptor beta variable 5-5 TRBV5-6T cell receptor beta variable 5-6 TRBV5-7T cell receptor beta variable 5-7 (non-functional) TRBV6-1T cell receptor beta variable 6-1 TRBV6-2T cell receptor beta variable 6-2 TRBV6-4T cell receptor beta variable 6-4 TRBV6-5T cell receptor beta variable 6-5 TRBV6-6T cell receptor beta variable 6-6 TRBV6-7T cell receptor beta variable 6-7 (non-functional) TRBV6-8T cell receptor beta variable 6-8 TRBV7-1T cell receptor beta variable 7-1 (non-functional) TRBV7-2T cell receptor beta variable 7-2 TRBV7-3T cell receptor beta variable 7-3 TRBV7-4T cell receptor beta variable 7-4 TRBV7-6T cell receptor beta variable 7-6 TRBV7-7T cell receptor beta variable 7-7 TRBV7-9T cell receptor beta variable 7-9 TRBV9T cell receptor beta variable 9 TRDCT cell receptor delta constant TRDD1T cell receptor delta diversity 1 TRDD2T cell receptor delta diversity 2 TRDD3T cell receptor delta diversity 3 TRDJ1T cell receptor delta joining 1 TRDJ2T cell receptor delta joining 2 TRDJ3T cell receptor delta joining 3 TRDJ4T cell receptor delta joining 4 TRDV2T cell receptor delta variable 2 TRDV3T cell receptor delta variable 3 TRGC1T cell receptor gamma constant 1 TRGC2T cell receptor gamma constant 2 TRGJ1T cell receptor gamma joining 1 TRGJ2T cell receptor gamma joining 2 TRGJPT cell receptor gamma joining P TRGJP1T cell receptor gamma joining P1 TRGJP2T cell receptor gamma joining P2 TRGV2T cell receptor gamma variable 2 TRGV3T cell receptor gamma variable 3 TRGV4T cell receptor gamma variable 4 TRGV5T cell receptor gamma variable 5 TRGV8T cell receptor gamma variable 8 TRGV9T cell receptor gamma variable 9 TRPC1transient receptor potential cation channel subfamily C member 1