Target List
Toll-Like Receptor (TLR) Signaling
Toll-Like Receptors & Chaperones
CTSB, CTSL, CTSS, TLR3, TLR7, TLR8, TLR9
Signaling Downstream of Toll-Like Receptors
CHUK (IKKα), FOS, IKBKB (IKKβ), IRAK1, IRF3, IRF5, IRF7, JUN, MAP2K1, MAP2K3 (MEK3), MAP3K7 (TAK1), MAPK1 (ERK2), MAPK14 (p38ALPHA), MAPK3 (ERK1), MAPK8 (JNK1), MYD88, NFKB1, NFKBIA (IκBα, MAD3), RELA, RIPK1, SPP1, TBK1, TICAM1 (TRIF), TNF, TRAF3, TRAF6
Toll-Like Receptor Signaling Responsive Genes
CCL3 (MIP-1A), CCL5 (RANTES), CD40 (TNFRSF5), CD80, CD86, CXCL10 (INP10), CXCL11 (I-TAC, IP-9), CXCL9 (MIG), IFNA1, IFNA2, IFNB1, IL12A, IL12B, IL15, IL1B, IL6
NOD-Like Receptor (NLR) Signaling
Receptors & Signaling Molecules
AIM2
NOD-Like Receptors & Signaling Molecules
CARD9, CASP1 (ICE), HSP90AA1, MEFV, NLRP3, NOD2, OAS2, PSTPIP1, PYCARD (TMS1, ASC), PYDC1 (POP1), SUGT1
NOD-Like Receptor Signaling Responsive Genes
IL1B, IL18
RIG-I-Like Receptor Signaling
Receptors & Chaperones
CYLD
RIG-I-Like Receptors & Chaperones
TKFC, DDX58, DHX58, IFIH1, ISG15, TRIM25
Signaling Downstream of RIG-I-Like Receptors
ATG5, AZI2, CASP10 (MCH4), CASP8 (FLICE), CHUK (IKKα), DDX3X, FADD, IKBKB (IKKβ), IRF3, IRF7, MAP3K1 (MEKK1), MAP3K7 (TAK1), MAPK14 (p38ALPHA), MAPK8 (JNK1), MAVS, NFKB1, NFKBIA (IκBα, MAD3), PIN1, RELA, RIPK1, TBK1, TNF, TRADD, TRAF3, TRAF6
RIG-I-Like Receptor Signaling Responsive Genes
CXCL10 (INP10), IFNA1, IFNA2, IFNB1, IL12A, IL12B, CXCL8 (IL8)
Type I Interferon Signaling & Response
Type I Interferon Signaling
IFNA1, IFNA2, IFNAR1, IFNB1, STAT1
Interferon Responsive Genes
APOBEC3G, IL15, ISG15, MX1, TLR3