Ubqln1 Gene Summary [Mouse]
Predicted to enable several functions, including identical protein binding activity; kinase binding activity; and polyubiquitin modification-dependent protein binding activity. Involved in negative regulation of toll-like receptor 3 signaling pathway. Located in autophagosome. Is expressed in liver. Orthologous to human UBQLN1 (ubiquilin 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ubqln1 |
| Official Name | ubiquilin 1 [Source:MGI Symbol;Acc:MGI:1860276] |
| Ensembl ID | ENSMUSG00000005312 |
| Bio databases IDs | |
| Aliases | ubiquilin 1 |
| Synonyms | 1110046H03Rik, 1810030E05Rik, D13Ertd372e, DA41, DSK2, PLIC-1, ubiquilin 1, UBQN, XDRP1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ubqln1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- UBA domain-like superfamily
- Ubiquitin family
- UV excision repair protein Rad23
- kinase binding
- Ubl1_cv_Nsp3_N-like
- Ubiquitin homologues
- protein domain specific binding
- STI1 domain
- protein binding
- ubiquitin-like domain
- identical protein binding
- Ubiquitin-2 like Rad60 SUMO-like
Pathways
Biological processes and signaling networks where the Ubqln1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- breast cancer
- metastasis
- Alzheimer disease
- colorectal cancer
- bleomycin-induced pulmonary fibrosis
- aortic valve calcification
- chromosomal instability
- neurodegeneration
role in cell
- phosphorylation in
- expression in
- proliferation
- reorganization
- processing in
- production in
- fusion
- cell viability
- cell death
- quantity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- aggresome
- cell surface
- cell periphery
- intracellular space
- perinuclear region
- Nucleus
- Plasma Membrane
- Golgi Apparatus
- Endoplasmic Reticulum
- cytosol
- postsynaptic membrane
- nucleoplasm
- neurites
- autophagic vacuoles
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ubqln1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- autophagic vacuole assembly
- negative regulation of toll-like receptor 3 signaling pathway
- regulation of macroautophagy
- positive regulation of protein ubiquitination
- regulation of protein ubiquitination
- cellular response to hypoxia
- aggrephagy
- macroautophagy
- response to endoplasmic reticulum stress
- ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- perinuclear region of cytoplasm
- cytoplasm
- cytoplasmic vesicle
- cytosol
- macromolecular complex
- proteasome complex
- endoplasmic reticulum
- aggresome
- plasma membrane
- autophagic vacuole
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- polyubiquitin binding
- kinase binding