Emx1 Gene Summary [Mouse]
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including nervous system development; neuroepithelial cell differentiation; and regulation of oligodendrocyte progenitor proliferation. Located in nucleus. Is expressed in several structures, including genitourinary system; ileum; nervous system; sensory organ; and surface ectoderm. Orthologous to human EMX1 (empty spiracles homeobox 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Emx1 |
| Official Name | empty spiracles homeobox 1 [Source:MGI Symbol;Acc:MGI:95387] |
| Ensembl ID | ENSMUSG00000033726 |
| Bio databases IDs | |
| Aliases | empty spiracles homeobox 1 |
| Synonyms | empty spiracles homeobox 1, RGD1564002 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Emx1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- double-stranded DNA binding
- protein binding
- sequence-specific DNA binding
- homeodomain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- chromosome
- nucleoli
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Emx1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuroepithelial cell differentiation
- neuron differentiation
- post-embryonic development
- radial glial cell differentiation
- brain morphogenesis
- brain development
- response to xenobiotic stimulus
- cerebral cortex regionalization
- cerebral cortex neuron differentiation
- regulation of transcription from RNA polymerase II promoter
- central nervous system development
- in utero embryonic development
- homeostasis of number of cells
- regulation of oligodendrocyte progenitor proliferation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- chromosome
- nucleolus
- chromatin
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity