Prop1 Gene Summary [Mouse]
Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and beta-catenin binding activity. Involved in negative regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including diencephalon development; dorsal/ventral pattern formation; and positive regulation of transcription by RNA polymerase II. Part of transcription regulator complex. Is expressed in Rathke's pouch; adenohypophysis; adenohypophysis pars anterior; embryo; and pituitary gland. Used to study hypopituitarism. Human ortholog(s) of this gene implicated in combined pituitary hormone deficiency 2; hypogonadism; and hypopituitarism. Orthologous to human PROP1 (PROP paired-like homeobox 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Prop1 |
| Official Name | paired like homeodomain factor 1 [Source:MGI Symbol;Acc:MGI:109330] |
| Ensembl ID | ENSMUSG00000044542 |
| Bio databases IDs | |
| Aliases | paired like homeodomain factor 1 |
| Synonyms | CPHD2, df, paired like homeodomain factor 1, PROP paired-like homeobox 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Prop1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- beta-catenin binding
- nucleic acid binding
- double-stranded DNA binding
- chromatin binding
- protein binding
- sequence-specific DNA binding
- homeodomain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- dyspnea
- combined pituitary hormone deficiency type 2
- hereditary disorder
- hypoplasia
- combined pituitary hormone deficiency
- hypopituitarism
- dwarfism
- atelectasis
- proportional dwarfism
role in cell
- apoptosis
- differentiation
- development
- quantity
- expansion
- specification
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Prop1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- hypothalamus cell differentiation
- positive regulation of transcription from RNA polymerase II promoter
- somatotropin secreting cell differentiation
- dorsal/ventral pattern formation
- regulation of transcription from RNA polymerase II promoter
- negative regulation of transcription from RNA polymerase II promoter
- central nervous system development
- blood vessel development
- hypophysis morphogenesis
- negative regulation of apoptotic process
- apoptotic process
- cell migration
Cellular Component
Where in the cell the gene product is active
- transcription factor complex
- nucleus
- chromatin
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
- chromatin binding
- beta-catenin binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity