GNA15
GNA15 Gene Summary
Enables G protein-coupled receptor binding activity. Involved in positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway. Predicted to be located in plasma membrane. Predicted to be part of heterotrimeric G-protein complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | GNA15 |
| Official Name | G protein subunit alpha 15 [Source:HGNC Symbol;Acc:HGNC:4383] |
| Ensembl ID | ENSG00000060558 |
| Bio databases IDs | |
| Aliases | G protein subunit alpha 15 |
| Synonyms | G15alpha,G15α,G[a]15,G Alpha15,G alpha 16,GNA16,G protein alpha 15,G protein subunit alpha 15,G protein subunit α 15,G protein α 15,G protein α 16,guanine nucleotide binding protein, alpha 15,guanine nucleotide binding protein, α 15,G α 15,G α 16,HG1L |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GTP binding
- G protein alpha subunit
- GTPase domain
- G-protein-coupled receptor binding
- GTPase
- G-protein alpha subunit
- enzyme
- P-loop containing Nucleoside Triphosphate Hydrolases
- phosphorylation site
Pathways
Biological processes and signaling networks where the GNA15 gene plays a role, providing insight into its function and relevance in health or disease.
- AMPK Signaling
- Androgen Signaling
- Apelin Endothelial Signaling Pathway
- Apelin Muscle Signaling Pathway
- Cardiac β-adrenergic Signaling
- CCR3 Signaling in Eosinophils
- CCR5 Signaling in Macrophages
- CXCR4 Signaling
- Endothelin-1 Signaling
- Ephrin B Signaling
- Ephrin Receptor Signaling
- fMLP Signaling in Neutrophils
- G Beta Gamma Signaling
- G Protein Signaling Mediated by Tubby
- GABA Receptor Signaling
- Gαi Signaling
- Gαq Signaling
- Huntington's Disease Signaling
- IL-1 Signaling
- IL-8 Signaling
- Molecular Mechanisms of Cancer
- PPARα/RXRα Activation
- RhoGDI Signaling
- Role of Tissue Factor in Cancer
- Synaptic Long Term Potentiation
- Thrombin Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- TTC1
- APP
- G protein beta gamma core
- USP11
- XTP-gamma-S
- RUNX1
- WDCP
- guanosine 5'-O-(3-thiotriphosphate)
- HSPA8
- GRK2
disease
- cancer
- alcoholism
- acute myeloid leukemia
- plaque psoriasis
- asthma
- heart failure
- epidermal hyperplasia
- cutaneous melanoma
- cutaneous melanoma cancer
- delayed hypersensitive reaction
regulated by
- tetradecanoylphorbol acetate
- lipopolysaccharide
- TNF
- HL 60 cells
- WNT3A
- neutrophils
- HMGA1
- PKC
- IL1B
- CXCL6
regulates
- PTGS2
- NFkB (complex)
- FPR2
- CCL23
- STAT3
- PLC
- inositol phosphate
- MAT2A
- Ca2+
- CHRM2
role in cell
- growth
- production in
- expression in
- outgrowth
- differentiation
- degranulation
- binding in
- phosphorylation in
- activation in
- signaling in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- axon initial segments
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the GNA15 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway
- regulation of action potential
- adenylate cyclase-modulating G-protein coupled receptor signaling pathway
- calcium-mediated signaling
- phospholipase C-activating dopamine receptor signaling pathway
CELLULAR COMPONENT
Where in the cell the gene product is active
- heterotrimeric G-protein complex
- cytoplasm
- synapse
- plasma membrane
MOLECULAR FUNCTION
What the gene product does at the molecular level
- GTP binding
- G-protein coupled receptor binding
- metal ion binding
- GTPase activity
- G-protein beta/gamma-subunit complex binding