PLD1
PLD1 Gene Summary
This gene encodes a phosphatidylcholine-specific phospholipase which catalyzes the hydrolysis of phosphatidylcholine in order to yield phosphatidic acid and choline. The enzyme may play a role in signal transduction and subcellular trafficking. Alternative splicing results in multiple transcript variants with both catalytic and regulatory properties. [provided by RefSeq, Sep 2011]
Details
| Type | Processed Transcript |
| Official Symbol | PLD1 |
| Official Name | phospholipase D1 [Source:HGNC Symbol;Acc:HGNC:9067] |
| Ensembl ID | ENSG00000075651 |
| Bio databases IDs | |
| Aliases | phospholipase D1, choline phosphatase 1 |
| Synonyms | C85393,CVDD,CVDP1,mPLD1,phospholipase D1,Pld1a,Pld1b,Plda,Pldb |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Phospholipase D Active site motif
- phospholipase D
- negative regulatory domain
- Lipase domain
- enzyme
- protein binding
- Pleckstrin homology-like domain
- Catalytic domain of phospholipase D superfamily proteins
- D4 domain
- PH domain
- PLD-like domain
- The Phox Homology domain, a phosphoinositide binding module
- loop domain
- PX domain
Pathways
Biological processes and signaling networks where the PLD1 gene plays a role, providing insight into its function and relevance in health or disease.
- Antioxidant Action of Vitamin C
- CTLA4 Signaling in Cytotoxic T Lymphocytes
- Endothelin-1 Signaling
- Fcγ Receptor-mediated Phagocytosis in Macrophages and Monocytes
- Gαq Signaling
- IL-8 Signaling
- mTOR Signaling
- p70S6K Signaling
- Pancreatic Adenocarcinoma Signaling
- Phagosome Formation
- Rac Signaling
- RhoA Signaling
- Serotonin Receptor Signaling
- Signaling by Rho Family GTPases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- TOP1
- TMEM63C
- FANCG
- GJD3
- RAB35
- HSPH1
- RHOA
- MIER2
- SEC62
- CACNG5
disease
- breast cancer
- neoplasia
- tumorigenesis
- cataract
- diabetes mellitus
- hereditary disorder
- cardiac valvular dysplasia type 1
- survival
- colorectal cancer
- renal cell cancer
regulated by
- Immunoglobulin
- quercetin
- D-glucose
- Ca2+
- rottlerin
- FOS
- adenosine triphosphate
- lipopolysaccharide
- Toxin-B
- IL1
regulates
- APP
- Collagen(s)
- IL6
- reactive oxygen species
- PTGS2
- ERK1/2
- BCL2L11
- LDL/cholesterol
- cholesterol
- diacylglycerol
role in cell
- proliferation
- expression in
- apoptosis
- binding
- migration
- production in
- activation in
- quantity
- outgrowth
- phosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- nuclear fraction
- membrane vesicles
- membrane fraction
- detergent resistant lipid raft fraction
- intracellular structures
- intracellular space
- perinuclear region
- cellular membrane
- focal adhesions
- filamentous network
- cell cortex
- Nucleus
- Plasma Membrane
- endosomes
- vesicles
- lysosome
- Golgi Apparatus
- Endoplasmic Reticulum
- granules
- tertiary granule membrane
- specific granule membrane
- cytosol
- endoplasmic reticulum membrane
- caveolar membranes
- apical membrane
- Golgi membrane
- trans Golgi network
- synapse
- Z line
- recycling endosomes
- perinuclear vesicles
- cytoplasmic vesicles
- endocytotic vesicle
- secretory granules
- Golgi cisternae
- membrane rafts
- detergent insoluble microdomains
- medial Golgi cisternae
- lamellipodia
- detergent-soluble fraction
- cytoskeletal fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the PLD1 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- chemotaxis
- positive regulation of translation
- cellular response to nutrient
- small GTPase mediated signal transduction
- phospholipid catabolic process
- Ras protein signal transduction
- regulation of vesicle-mediated transport
- phosphatidic acid biosynthetic process
- regulation of microvillus assembly
CELLULAR COMPONENT
Where in the cell the gene product is active
- Golgi apparatus
- Golgi membrane
- lysosomal membrane
- plasma membrane
- endoplasmic reticulum membrane
- late endosome membrane
- endocytic vesicle
- perinuclear region of cytoplasm
- endosome
- intracellular membrane-bounded organelle
- membrane
- tertiary granule membrane
- apical plasma membrane
- specific granule membrane
MOLECULAR FUNCTION
What the gene product does at the molecular level
- protein binding
- phosphatidylinositol binding
- NAPE-specific phospholipase D activity
- phospholipase D activity