ARHGEF1
ARHGEF1 Gene Summary
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate Rho-dependent signals. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | ARHGEF1 |
| Official Name | Rho guanine nucleotide exchange factor 1 [Source:HGNC Symbol;Acc:HGNC:681] |
| Ensembl ID | ENSG00000076928 |
| Bio databases IDs | |
| Aliases | Rho guanine nucleotide exchange factor 1 |
| Synonyms | GEF1,IMD62,LBCL2,LOC100505585,LOC100508117,LSC,P115-RHOGEF,Rho guanine nucleotide exchange factor 1,SUB1.5 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RhoGEF
- Regulator of G protein signalling-like domain
- guanyl-nucleotide exchange factor
- RGS homology domain
- PH domain
- Regulator of G protein signaling (RGS) domain superfamily
- coiled-coil domain
- protein binding
- Pleckstrin homology-like domain
- Dbl homology domain
- RhoGEF domain
Pathways
Biological processes and signaling networks where the ARHGEF1 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- JUNB
- LRRC59
- MYC
- SGIP1
- SNW1
- NTRK1
- PINK1
- UNK
- THBS3
- AP2S1
disease
- metastasis
- immunodeficiency 62
- Huntington disease
- hypertension
- B-cell non-Hodgkin disease
- mature B-cell neoplasia
- IG-MYC translocation positive Burkitt lymphoma
- hallux valgus
regulated by
- cyclosporin A
- MYC
- epigallocatechin-gallate
- arachidonic acid
- tretinoin
- GNA13
- GNA12
- F2
- AGT
- IL3
regulates
- reactive oxygen species
- JNK
- Ca2+
- FOS
- NFkB (complex)
- IgG
- CCND1
- AKT
- ICAM1
- CDC42
role in cell
- formation
- phosphorylation in
- activation in
- apoptosis
- growth
- cell viability
- migration
- proliferation
- binding in
- reorganization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Plasma Membrane
- cytosol
- pseudopodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the ARHGEF1 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- G-protein coupled receptor signaling pathway
- regulation of small GTPase mediated signal transduction
- Rho protein signal transduction
CELLULAR COMPONENT
Where in the cell the gene product is active
- cytoplasm
- cytosol
- plasma membrane
MOLECULAR FUNCTION
What the gene product does at the molecular level
- G-protein coupled receptor binding
- protein binding
- RNA binding
- guanyl-nucleotide exchange factor activity
- GTPase activator activity