MAP2K7
MAP2K7 Gene Summary
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2,MAP3K3/MEKK5, and MAP4K2/GCK. This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Details
| Type | Protein Coding |
| Official Symbol | MAP2K7 |
| Official Name | mitogen-activated protein kinase kinase 7 [Source:HGNC Symbol;Acc:HGNC:6847] |
| Ensembl ID | ENSG00000076984 |
| Bio databases IDs | |
| Aliases | mitogen-activated protein kinase kinase 7 |
| Synonyms | 5930412N11Rik,JNKK,JNKK 2,MAPK2K7,MAPKK 7,Mapkk7 protein 2,MEK,MEK 7,mitogen-activated protein kinase kinase 7,MKK7,Mkk7 beta1,PRKMK7,SAPKK-4,sek2 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein threonine/tyrosine kinase
- Protein kinase (unclassified specificity)
- protein kinase binding
- ATP-binding domain
- Protein tyrosine and serine/threonine kinase
- protein phosphatase binding
- ATP binding
- JUN kinase kinase
- enzyme binding
- protein binding
- magnesium ion binding
- Protein kinase domain
- kinase
- MAP kinase kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- Protein Kinases, catalytic domain
- MAP kinase
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the MAP2K7 gene plays a role, providing insight into its function and relevance in health or disease.
- Acute Myeloid Leukemia Signaling
- Acute Phase Response Signaling
- Apoptosis Signaling
- April Mediated Signaling
- B Cell Activating Factor Signaling
- CD27 Signaling in Lymphocytes
- CD40 Signaling
- Death Receptor Signaling
- GADD45 Signaling
- Glucocorticoid Receptor Signaling
- HGF Signaling
- HIF1α Signaling
- IL-15 Production
- Induction of Apoptosis by HIV1
- Melatonin Signaling
- Neurotrophin/TRK Signaling
- NF-κB Signaling
- Polyamine Regulation in Colon Cancer
- PPARα/RXRα Activation
- RANK Signaling in Osteoclasts
- Reelin Signaling in Neurons
- Regulation of IL-2 Expression in Activated and Anergic T Lymphocytes
- Role of MAPK Signaling in the Pathogenesis of Influenza
- Type II Diabetes Mellitus Signaling
- Unfolded protein response
- Xenobiotic Metabolism Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- FBXO6
- JUN
- WDR62
- THUMPD3
- CPVL
- CD40
- DUSP19
- MAPK8
- ARR3
- HSCB
disease
- neoplasia
- hyperplasia
- non-insulin-dependent diabetes mellitus
- endometriosis
- metabolic syndrome X
- reperfusion injury
- neuroblastoma
- neuroblastoma formation
- neonatal late-onset sepsis
regulated by
- MAP3K7
- FGFR2
- ENV
- insulin
- FLNA
- MAPK8
- KDM5A
- LEF
- MAPK8IP1
- TP53
regulates
- MYC
- CXCL8
- NFkB (complex)
- CCL5
- MAPK8
- p38 MAPK
- TNF
- IL4
- Ap1
- BAD
role in cell
- apoptosis
- expression in
- proliferation
- formation
- response
- growth
- phosphorylation in
- transcription in
- quantity
- activation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microsomal fraction
- nuclear fraction
- pH resistant lipid raft fraction
- Nucleus
- cytosol
- actin stress fibers
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the MAP2K7 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- positive regulation of JUN kinase activity
- signal transduction
- cellular senescence
- response to wounding
- response to osmotic stress
- Fc-epsilon receptor signaling pathway
- response to UV
- JNK cascade
- positive regulation of telomerase activity
- response to heat
- cellular response to lipopolysaccharide
- positive regulation of transcription, DNA-dependent
- positive regulation of JNK cascade
- positive regulation of ERK1 and ERK2 cascade
- apoptotic process
- cellular response to interleukin-1
- positive regulation of telomere maintenance via telomerase
- regulation of motor neuron apoptotic process
- stress-activated MAPK cascade
- response to tumor necrosis factor
CELLULAR COMPONENT
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
MOLECULAR FUNCTION
What the gene product does at the molecular level
- magnesium ion binding
- ATP binding
- protein kinase binding
- protein tyrosine kinase activity
- protein phosphatase binding
- protein binding
- MAP kinase kinase activity
- MAP kinase activity
- JUN kinase kinase activity
- enzyme binding