CXCL2
CXCL2 Gene Summary
This antimicrobial gene is part of a chemokine superfamily that encodes secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CXC subfamily, is expressed at sites of inflammation and may suppress hematopoietic progenitor cell proliferation. [provided by RefSeq, Sep 2014]
Details
| Type | Protein Coding |
| Official Symbol | CXCL2 |
| Official Name | C-X-C motif chemokine ligand 2 [Source:HGNC Symbol;Acc:HGNC:4603] |
| Ensembl ID | ENSG00000081041 |
| Bio databases IDs | |
| Aliases | C-X-C motif chemokine ligand 2 |
| Synonyms | CINC-2a,C-X-C motif chemokine ligand 2,GRO2,GROb,Gro β,MGSA-b,MIP2,MIP-2a,Mip2 α,SCYB2 |
| Species | Human, homo_sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- chemokine
- Small cytokines (intecrine/chemokine), interleukin-8 like
- protein binding
- PDZ binding motif
Pathways
Biological processes and signaling networks where the CXCL2 gene plays a role, providing insight into its function and relevance in health or disease.
- Agranulocyte Adhesion and Diapedesis
- Airway Pathology in Chronic Obstructive Pulmonary Disease
- Glucocorticoid Receptor Signaling
- Granulocyte Adhesion and Diapedesis
- Hepatic Fibrosis / Hepatic Stellate Cell Activation
- IL-17 Signaling
- IL-17A Signaling in Airway Cells
- Role of Hypercytokinemia/hyperchemokinemia in the Pathogenesis of Influenza
- Role of IL-17A in Arthritis
- TREM1 Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- CDK9
- PF4
- CCL5
- Orf74
- CXCL2
- ARID5A
- CXCL14
- RNA polymerase II
- NR1I2
- MAZ
disease
- invasive breast cancer
- squamous cell cancer of the oral cavity
- head and neck squamous cell carcinoma
- ischemic stroke
- obesity
- breast cancer
- familial hemophagocytic lymphohistiocytosis
- diabetic nephropathy
- metastasis
- osteoarthritis
regulated by
- RELA
- D-glucose
- dexamethasone
- RXRA
- AMH
- glutamine
- TNF
- etoposide
- SB203580
- Caco2 cells
regulates
- Ca2+
- ITGAM
- Orf74
- IFRD1
- metalloprotease
role in cell
- expression in
- growth
- proliferation
- migration
- survival
- chemotaxis
- recruitment
- mobilization in
- adhesion
- invasion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the CXCL2 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- chemotaxis
- response to molecule of bacterial origin
- inflammatory response
- cellular response to lipopolysaccharide
- chemokine-mediated signaling pathway
- neutrophil chemotaxis
CELLULAR COMPONENT
Where in the cell the gene product is active
- extracellular space
- extracellular region
MOLECULAR FUNCTION
What the gene product does at the molecular level
- protein binding
- CXCR chemokine receptor binding
- chemokine activity