ITGA6
ITGA6 Gene Summary
The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 6 subunit. This subunit may associate with a beta 1 or beta 4 subunit to form an integrin that interacts with extracellular matrix proteins including members of the laminin family. The alpha 6 beta 4 integrin may promote tumorigenesis, while the alpha 6 beta 1 integrin may negatively regulate erbB2/HER2 signaling. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
Details
| Type | Protein Coding |
| Official Symbol | ITGA6 |
| Official Name | integrin subunit alpha 6 [Source:HGNC Symbol;Acc:HGNC:6142] |
| Ensembl ID | ENSG00000091409 |
| Bio databases IDs | |
| Aliases | integrin subunit alpha 6 |
| Synonyms | 5033401O05Rik,CD49f,integrin alpha 6,integrin subunit alpha 6,integrin subunit α 6,Integrin-α 6,ITGA6A,ITGA6B,ITG alpha6,JEB6,VLA-6 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Integrin alpha cytoplasmic region
- extracellular domain
- insulin-like growth factor binding
- protein binding
- FG-GAP-like repeat
- Integrin alpha (beta-propellor repeats)
- binding protein
- Integrin alpha
- cytoplasmic domain
- laminin binding
- intracellular domain
- cytosolic tail domain
- FG-GAP repeat
- PDZ binding motif
- transmembrane receptor
- growth factor binding
Pathways
Biological processes and signaling networks where the ITGA6 gene plays a role, providing insight into its function and relevance in health or disease.
- Actin Cytoskeleton Signaling
- Actin Nucleation by ARP-WASP Complex
- Caveolar-mediated Endocytosis Signaling
- CDK5 Signaling
- Ephrin Receptor Signaling
- ERK/MAPK Signaling
- Germ Cell-Sertoli Cell Junction Signaling
- HGF Signaling
- Integrin Signaling
- NF-κB Activation by Viruses
- PAK Signaling
- Paxillin Signaling
- PTEN Signaling
- Rac Signaling
- Regulation of Actin-based Motility by Rho
- Regulation of Cellular Mechanics by Calpain Protease
- Regulation of eIF4 and p70S6K Signaling
- RhoGDI Signaling
- Role of Tissue Factor in Cancer
- Sertoli Cell-Sertoli Cell Junction Signaling
- TEC Kinase Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- RHOA
- CDC42
- RAC1
- RAB7A
- HRAS
- RAC2
- EZR
- ARF6
- RAB2A
- ERBB2
disease
- neoplasia
- tumorigenesis
- colon cancer
- metastasis
- cancer
- prostate cancer
- oral squamous cell carcinoma
- squamous cell cancer of the oral cavity
- prostatic carcinoma
- epithelial cancer
regulated by
- EGF
- tetradecanoylphorbol acetate
- PI3K (complex)
- MYC
- SOS
- KRAS
- TIAM1
- RAB11
- dexamethasone
- insulin
regulates
- BAX
- BCL2
- BCL2L1
- CASP3
- AKT
- MMP1
- ERK1/2
- TP53
- progesterone
- CCN1
role in cell
- cell death
- apoptosis
- expression in
- proliferation
- production in
- cell viability
- activation in
- phosphorylation in
- formation
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- hemidesmosome-like structure
- extracellular vesicles
- Cytoplasm
- cell surface
- cell borders
- cell periphery
- basal compartment
- membrane surface
- cellular membrane
- retraction fibers
- intercellular junctions
- hemidesmosomes
- basal cell surfaces
- basolateral cell surfaces
- plasma membrane extracellular face
- basolateral membrane
- basal membrane
- lateral plasma membrane
- zona pellucida
- abaxonal membranes
- perinuclear vesicles
- filopodia
- cell membrane leading edge
- filopodial shafts
- perikaryon
- exosomes
- cell-cell adherens junctions
- basement membrane
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the ITGA6 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- positive regulation of phosphorylation
- cell-matrix adhesion
- cell-substrate junction assembly
- skin morphogenesis
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of GTPase activity
- integrin-mediated signaling pathway
- cell adhesion mediated by integrin
- positive regulation of apoptotic process
- negative regulation of extrinsic apoptotic signaling pathway
- nail development
- positive regulation of neuron projection development
- leukocyte migration
- positive regulation of cell-substrate adhesion
- ectodermal cell differentiation
- cell-substrate adhesion
- cellular response to organic cyclic compound
- positive regulation of cell migration
CELLULAR COMPONENT
Where in the cell the gene product is active
- adherens junction
- focal adhesion
- external side of plasma membrane
- filopodium
- alpha6-beta4 integrin complex
- alpha6-beta1 integrin complex
- integrin complex
- plasma membrane
- cell surface
MOLECULAR FUNCTION
What the gene product does at the molecular level
- protein binding
- neuregulin binding
- metal ion binding
- cadherin binding
- integrin binding
- laminin binding
- insulin-like growth factor I binding