MAP3K20
MAP3K20 Gene Summary
This gene is a member of the MAPKKK family of signal transduction molecules and encodes a protein with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif (SAM). This magnesium-binding protein forms homodimers and is located in the cytoplasm. The protein mediates gamma radiation signaling leading to cell cycle arrest and activity of this protein plays a role in cell cycle checkpoint regulation in cells. The protein also has pro-apoptotic activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | MAP3K20 |
| Official Name | mitogen-activated protein kinase kinase kinase 20 [Source:HGNC Symbol;Acc:HGNC:17797] |
| Ensembl ID | ENSG00000091436 |
| Bio databases IDs | |
| Aliases | mitogen-activated protein kinase kinase kinase 20, ZAK1 homolog, leucine zipper and sterile-alpha motif kinase (Dictyostelium), mixed lineage kinase 7 |
| Synonyms | AZK,B230120H23Rik,CNM6,HCCS-4,mitogen-activated protein kinase kinase kinase 20,MLK7,mlklak,MLT,MLTK,MLTK alpha,MLTKbeta,MLTK α,MRK,pk,RGD1561394,SFMMP,ZAK |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- rRNA binding
- Protein tyrosine and serine/threonine kinase
- SAM (Sterile alpha motif )
- ATP binding
- JUN kinase kinase kinase
- protein kinase regulator
- protein binding
- magnesium ion binding
- Protein kinase domain
- MAP kinase kinase kinase
- kinase
- protein kinase activator
- Serine/Threonine protein kinases, catalytic domain
- Sterile alpha motif
- Protein Kinases, catalytic domain
- ribosome binding
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the MAP3K20 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- ESR1
- ESR2
- CDC42
- TP53
- SMARCB1
- MYC
- ITSN1
- ELAVL1
- CDK1
- PARD6A
disease
- split-foot malformation with mesoaxial polydactyly
- androgenic alopecia
- Alzheimer disease
- centronuclear myopathy 6 with fiber-type disproportion
- dermatitis
- colorectal adenoma
- colorectal adenoma formation
- dementia
- colorectal carcinomagenesis
- abdominal aortic aneurysm
regulated by
- tetradecanoylphorbol acetate
- CSF2
- EGF
- IL2
- TNF
- ESR1
- PRPF6
- NR3C1
- SOS
- Mir133c
regulates
- CCN2
- CXCL8
- hemoglobin
- JUN
- YAP1
- JNK
- MAP2K4/7
- IL6
- ERK
- LATS1
role in cell
- expression in
- invasion
- phosphorylation in
- activation in
- migration
- cellular infiltration by
- quantity
- invasion by
- apoptosis
- transformation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the MAP3K20 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- regulation of mitotic metaphase/anaphase transition
- cytoskeleton organization
- p38MAPK cascade
- limb development
- stress-activated protein kinase signaling cascade
- positive regulation of programmed cell death
- protein autophosphorylation
- chromosome segregation
- JNK cascade
- protein phosphorylation
- embryonic digit morphogenesis
- cellular response to UV-B
- MAPK cascade
- DNA damage checkpoint
- cellular response to gamma radiation
- inflammatory response
- cell death
- positive regulation of apoptotic process
- cell differentiation
- pyroptosis
- peptidyl-serine phosphorylation
- stress-activated MAPK cascade
CELLULAR COMPONENT
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
MOLECULAR FUNCTION
What the gene product does at the molecular level
- magnesium ion binding
- ATP binding
- RNA binding
- protein binding
- protein kinase activator activity
- JUN kinase kinase kinase activity
- ribosome binding
- MAP kinase kinase kinase activity
- protein serine/threonine kinase activity
- SSU rRNA binding