ARHGEF7
ARHGEF7 Gene Summary
This gene encodes a protein that belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It forms a complex with the small GTP binding protein Rac1 and recruits Rac1 to membrane ruffles and to focal adhesions. Multiple alternatively spliced transcript variants encoding different isoforms have been observed for this gene. [provided by RefSeq, Mar 2016]
Details
| Type | Processed Transcript |
| Official Symbol | ARHGEF7 |
| Official Name | Rho guanine nucleotide exchange factor 7 [Source:HGNC Symbol;Acc:HGNC:15607] |
| Ensembl ID | ENSG00000102606 |
| Bio databases IDs | |
| Aliases | Rho guanine nucleotide exchange factor 7, SH3 domain-containing proline-rich protein, PAK-interacting exchange factor beta |
| Synonyms | ARHG7,beta1PIX,BETA-PIX,betaPix-b,betaPix-c,Beta-Pix Cool,Cool,COOL-1,mKIAA0142,Nbla10314,P50,P50BP,P85,P85 beta pix,P85COOL1,P85SPR,P85 β pix,PAK3,Pak3bp,PAK-INTERACTING EXCHANGE FACTOR beta,PAK-INTERACTING EXCHANGE FACTOR β,PIX,PIXB,Rho guanine nucleotide exchange factor,Rho guanine nucleotide exchange factor 7,β-PIX,β Pix-a,β-Pix Cool |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Unstructured region two on RhoGEF 6 and 7
- leucine zipper domain
- betaPIX coiled coil
- Arf-GAP domain
- proline rich domain
- PH domain
- Dbl homology domain
- GTP binding domain
- dimerization domain
- protein kinase binding
- Calponin homology domain
- enzyme binding
- glutamic acid-rich domain
- protein binding
- Pleckstrin homology-like domain
- T1 domain
- RhoGEF domain
- Src Homology 3 domain superfamily
- gamma-tubulin binding
- RhoGEF
- histidine-rich region
- guanyl-nucleotide exchange factor
- Unstructured region one on RhoGEF 6 and 7
- calponin homology (CH) domain superfamily
- PDZ binding motif
Pathways
Biological processes and signaling networks where the ARHGEF7 gene plays a role, providing insight into its function and relevance in health or disease.
- Actin Cytoskeleton Signaling
- Agrin Interactions at Neuromuscular Junction
- Axonal Guidance Signaling
- Breast Cancer Regulation by Stathmin1
- FAK Signaling
- Integrin Signaling
- Molecular Mechanisms of Cancer
- PAK Signaling
- Paxillin Signaling
- Reelin Signaling in Neurons
- RhoGDI Signaling
- Signaling by Rho Family GTPases
- Thrombin Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- MAPT
- EGFR
- SLC6A4
- ZRANB1
- SHANK1
- RIGI
- ZYX
- YWHAG
- CAMK4
- PAK3
disease
- insomnia
- azoxymethane/dextran sodium sulfate induced colorectal cancer
- nonsyndromic X-linked mental retardation
- breast carcinoma
- growth failure
- epileptic seizure
- Huntington disease
- primary myelofibrosis
regulated by
- FGF2
- EDN1
- forskolin
- acetylcholine
- GIT1
- D-glucose
- ARHGEF7
- PAK1
- ADORA2A
- CBL
regulates
- PXN
- IL2
- luciferase reporter gene
- synthetic promoter
- dopamine
- CDKN1B
- MAPK14
- SHC1
- PAK1
- SLC9A3
role in cell
- chemotaxis
- phosphorylation in
- formation
- formation in
- apoptosis
- migration
- quantity
- expression in
- binding in
- proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- postsynaptic density (PSD) fractions
- membrane fraction
- synaptosomal membrane fractions
- cell periphery
- apical compartment
- postsynaptic region
- focal adhesions
- Nucleus
- vacuole
- Plasma Membrane
- centrosome
- cytosol
- membrane ruffles
- spindle pole
- growth cone
- neurites
- synaptosomes
- synapse
- cytoplasmic vesicles
- perikaryon
- lamellipodia
- synaptic vesicle fractions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the ARHGEF7 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- positive regulation of lamellipodium morphogenesis
- signal transduction
- Golgi organization
- nervous system development
- positive regulation of substrate adhesion-dependent cell spreading
- Rho protein signal transduction
- positive regulation of GTPase activity
- positive regulation of apoptotic process
- ephrin receptor signaling pathway
- lamellipodium assembly
- focal adhesion assembly
- positive regulation of fibroblast migration
CELLULAR COMPONENT
Where in the cell the gene product is active
- centrosome
- focal adhesion
- cytoplasm
- cell cortex
- ruffle
- cytosol
- macromolecular complex
- neuronal cell body
- neuron projection
- lamellipodium
MOLECULAR FUNCTION
What the gene product does at the molecular level
- protein kinase binding
- protein binding
- guanyl-nucleotide exchange factor activity
- gamma-tubulin binding