CCL22
CCL22 Gene Summary
This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 16. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for monocytes, dendritic cells, natural killer cells and for chronically activated T lymphocytes. It also displays a mild activity for primary activated T lymphocytes and has no chemoattractant activity for neutrophils, eosinophils and resting T lymphocytes. The product of this gene binds to chemokine receptor CCR4. This chemokine may play a role in the trafficking of activated T lymphocytes to inflammatory sites and other aspects of activated T lymphocyte physiology. [provided by RefSeq, Sep 2014]
Details
| Type | Protein Coding |
| Official Symbol | CCL22 |
| Official Name | C-C motif chemokine ligand 22 [Source:HGNC Symbol;Acc:HGNC:10621] |
| Ensembl ID | ENSG00000102962 |
| Bio databases IDs | |
| Aliases | C-C motif chemokine ligand 22 |
| Synonyms | A-152E5.1,ABCD-1,C-C motif chemokine ligand 22,DCBCK,DC/B-CK,Macrophage Chemotactic Protein 1,MDC,SCYA22,STCP-1 |
| Species | Human, homo_sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- chemokine
- Small cytokines (intecrine/chemokine), interleukin-8 like
- protein binding
- cytokine
Pathways
Biological processes and signaling networks where the CCL22 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- ACKR2
- ZNG1A
- RAD51D
- CCR4
- OAF
- LNPEP
- NR2F1
- ZIC1
- CD109
- CCL14
disease
- allodynia
- infection
- atopic dermatitis
- systemic lupus erythematosus
- proteinuria
- neoplasia
- insulin-dependent diabetes mellitus
- liver disease
- rheumatoid arthritis
- chronic natural killer lymphoproliferative disorder
regulated by
- lipopolysaccharide
- imiquimod
- IL1B
- KITLG
- IL10
- cytokine
- prostaglandin E2
- TNF
- E. coli B5 lipopolysaccharide
- IGHE
regulates
- Ca2+
- AKT
- beta arrestin
- TNF
- Cxcl1
- TAC1
- creatinine
- PTK2
- CCR4
- Cxcl2
role in cell
- expression in
- activity
- activation in
- migration
- phosphorylation in
- chemotaxis
- activation
- adhesion
- binding
- proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- cell surface
- intracellular space
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the CCL22 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- chemotaxis
- inflammatory response
- immune response
- signal transduction
- eosinophil chemotaxis
- chemokine-mediated signaling pathway
- cell-cell signaling
- response to virus
- positive regulation of GTPase activity
- positive regulation of cell migration
CELLULAR COMPONENT
Where in the cell the gene product is active
- extracellular space
- extracellular region
MOLECULAR FUNCTION
What the gene product does at the molecular level
- CCR chemokine receptor binding
- protein binding
- chemokine activity