CCL17
CCL17 Gene Summary
This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 16. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for T lymphocytes, but not monocytes or granulocytes. The product of this gene binds to chemokine receptors CCR4 and CCR8. This chemokine plays important roles in T cell development in thymus as well as in trafficking and activation of mature T cells. [provided by RefSeq, Sep 2014]
Details
| Type | Protein Coding |
| Official Symbol | CCL17 |
| Official Name | C-C motif chemokine ligand 17 [Source:HGNC Symbol;Acc:HGNC:10615] |
| Ensembl ID | ENSG00000102970 |
| Bio databases IDs | |
| Aliases | C-C motif chemokine ligand 17 |
| Synonyms | A-152E5.3,ABCD-2,C-C motif chemokine ligand 17,SCYA17,Scya17l,TARC |
| Species | Human, homo_sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CCR chemokine receptor binding
- chemokine
- Small cytokines (intecrine/chemokine), interleukin-8 like
- protein binding
- receptor binding
- cytokine
Pathways
Biological processes and signaling networks where the CCL17 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- CCR4
- RXRA
- NR1H3
- VCAM1
- CCL28
- SDC1
- SREBF1
- ACKR1
- CCR5
- BIRC6
disease
- infection
- preeclampsia
- renal clear cell adenocarcinoma
- renal clear cell cancer
- airway hyperresponsiveness
- breast carcinoma
- atopic dermatitis
- T-cell large granular lymphocytic leukemia
- papillary thyroid carcinoma
- papillary thyroid cancer
regulated by
- IL4
- RXRA
- TREM1
- IL21
- IL13
- IL12 (complex)
- IL33
- vorinostat
- Fc gamma receptor
- ESRRA
regulates
- MAPK1
- ADRB2
- Ca2+
- VCAM1
- PI3K (complex)
- CCR4
- GRK2
- CCR8
- beta arrestin
- HAMP
role in cell
- expression in
- differentiation
- migration
- proliferation
- inhibition in
- chemotaxis
- activation
- formation
- emigration
- mobility
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- cell surface
- intracellular space
- apical compartment
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the CCL17 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- chemotaxis
- inflammatory response
- chemokine-mediated signaling pathway
- cell-cell signaling
- positive regulation of GTPase activity
- positive regulation of cell migration
- cell chemotaxis
CELLULAR COMPONENT
Where in the cell the gene product is active
- extracellular space
- extracellular region
MOLECULAR FUNCTION
What the gene product does at the molecular level
- CCR chemokine receptor binding
- protein binding
- chemokine activity
- receptor binding