PARD6A
PARD6A Gene Summary
This gene is a member of the PAR6 family and encodes a protein with a PSD95/Discs-large/ZO1 (PDZ) domain and a semi-Cdc42/Rac interactive binding (CRIB) domain. This cell membrane protein is involved in asymmetrical cell division and cell polarization processes as a member of a multi-protein complex. The protein also has a role in the epithelial-to-mesenchymal transition (EMT) that characterizes the invasive phenotype associated with metastatic carcinomas. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | PARD6A |
| Official Name | par-6 family cell polarity regulator alpha [Source:HGNC Symbol;Acc:HGNC:15943] |
| Ensembl ID | ENSG00000102981 |
| Bio databases IDs | |
| Aliases | par-6 family cell polarity regulator alpha |
| Synonyms | 0710008C04Rik,2610010A15RIK,MPAR6,PAR6,PAR-6A,PAR6alpha,PAR6C,par-6 family cell polarity regulator alpha,par-6 family cell polarity regulator α,TAX40,TIP-40 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain present in PSD-95, Dlg, and ZO-1/2
- GTP-dependent protein binding
- canonical PDZ domain
- enzyme binding
- protein binding
- PDZ domain
- PB1
- Phox and Bem1 domain
Pathways
Biological processes and signaling networks where the PARD6A gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- PIK3R4
- PALS1
- CRB3
- PKC lambda/iota
- PARD6B
- PRKCI
- LLGL2
- PNMA1
- PRKCZ
- PTPN21
disease
- neoplastic cell transformation
regulated by
- aurothiomalate
- CSPG4
- aurothioglucose
- RAC1
- CDC42
- CDX2
- RHOQ
- levodopa
- PARD6A
- guanosine triphosphate
regulates
- AKT1
- MAPT
- MMP10
- agar
- PARD6A
- PARD3
- atypical protein kinase C
- ECT2
- IRS1
- p85 PIK3R
role in cell
- expression in
- phosphorylation in
- formation
- growth
- binding in
- inhibition in
- polarization
- loss
- invasion by
- movement
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell junction
- axon component
- Cytoplasm
- perinuclear region
- cell cortex
- Nucleus
- centrosome
- cell-cell contacts
- cytosol
- primary cilia
- membrane ruffles
- spindle pole
- nuclear speckles
- growth cone
- tight junctions
- mitotic spindle
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the PARD6A gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- cell division
- regulation of cellular localization
- centrosome cycle
- negative regulation of protein phosphorylation
- establishment or maintenance of epithelial cell apical/basal polarity
- establishment or maintenance of cell polarity
- viral reproduction
- positive regulation of protein secretion
- cell-cell junction maintenance
CELLULAR COMPONENT
Where in the cell the gene product is active
- nucleus
- tight junction
- centrosome
- occluding junction
- centriolar satellite
- cell cortex
- ruffle
- cytosol
- plasma membrane
- apical plasma membrane
MOLECULAR FUNCTION
What the gene product does at the molecular level
- protein binding
- small GTPase binding
- GTP-dependent protein binding