C5

C5 Gene Summary

This gene encodes a component of the complement system, a part of the innate immune system that plays an important role in inflammation, host homeostasis, and host defense against pathogens. The encoded preproprotein is proteolytically processed to generate multiple protein products, including the C5 alpha chain, C5 beta chain, C5a anaphylatoxin and C5b. The C5 protein is comprised of the C5 alpha and beta chains, which are linked by a disulfide bridge. Cleavage of the alpha chain by a convertase enzyme results in the formation of the C5a anaphylatoxin, which possesses potent spasmogenic and chemotactic activity, and the C5b macromolecular cleavage product, a subunit of the membrane attack complex (MAC). Mutations in this gene cause complement component 5 deficiency, a disease characterized by recurrent bacterial infections. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2015]

Details

Type
Protein Coding
Official Symbol
C5
Official Name
complement C5 [Source:HGNC Symbol;Acc:HGNC:1331]
Ensembl ID
ENSG00000106804
Bio databases IDs NCBI: 727 Ensembl: ENSG00000106804
Aliases complement C5, prepro-C5, C5a anaphylatoxin
Synonyms
C5a,C5D,Complement C5,Complement Component C5/C5a,complement pathway protein C5,CPAMD4,ECLZB,haemolytic complement,Hc,He,hemolytic complement,Hfib2,RGD1561905
Species
Human, homo_sapiens

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • Alpha-2-macroglobulin bait region domain
  • Macroglobulin domain MG4
  • G-protein-coupled receptor binding
  • A-macroglobulin receptor binding domain
  • protein binding
  • receptor binding
  • cytokine
  • Macroglobulin domain MG3
  • NTR_like
  • ISOPREN_C2_like
  • chemokine
  • A-macroglobulin TED domain
  • Macroglobulin domain MG1
  • extracellular loop
  • ANATO
  • Alpha-2-macroglobulin family
  • MG2 domain

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
  • C8
  • C5AR1
  • PHF11
  • JUN
  • KEL
  • CPB2
  • C6
  • CREB3L1
  • avacincaptad pegol
  • zilucoplan
disease
  • pain
  • asthma
  • schizophrenia
  • septic shock
  • severe sepsis
  • fibrosis
  • plasma cell myeloma
  • atypical hemolytic uremic syndrome
  • airway hyperresponsiveness
  • autoimmune disease
regulated by
  • hydrogen peroxide
  • beta tryptase
  • IFNG
  • FOXA2
  • 1,2-dithiole-3-thione
  • CXCR4
  • Filoviridae
  • neutrophils
  • JUN
  • C3AR1
regulates
  • STAT3
  • ICAM1
  • BCL2
  • CCND1
  • BCL2L1
  • IL6
  • CXCL1
  • FLT1
  • JNK
  • ITGB2
role in cell
  • expression in
  • phosphorylation in
  • apoptosis
  • proliferation
  • binding
  • activation in
  • activity
  • migration
  • differentiation
  • chemotaxis

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Extracellular Space
  • Cytoplasm
  • cell surface
  • Nucleus
  • apical cell surfaces
  • plasma

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the C5 gene, providing context for its role in the cell.

BIOLOGICAL PROCESS

Functions and activities the gene product is involved in
  • complement activation, alternative pathway
  • chemotaxis
  • inflammatory response
  • G-protein coupled receptor signaling pathway
  • complement activation, classical pathway
  • killing of cells of other organism
  • cell surface receptor signaling pathway
  • positive regulation of chemokine production
  • negative regulation of macrophage chemotaxis
  • positive regulation vascular endothelial growth factor production
  • cell chemotaxis

CELLULAR COMPONENT

Where in the cell the gene product is active
  • membrane attack complex
  • extracellular space
  • extracellular vesicular exosome
  • extracellular region

MOLECULAR FUNCTION

What the gene product does at the molecular level
  • protein binding
  • endopeptidase inhibitor activity
  • chemokine activity
  • receptor binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.