PIP5K1B
PIP5K1B Gene Summary
Predicted to enable 1-phosphatidylinositol-4-phosphate 5-kinase activity. Predicted to be involved in regulation of phosphatidylinositol 3-kinase signaling. Predicted to act upstream of or within phosphatidylinositol biosynthetic process. Located in uropod. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | PIP5K1B |
| Official Name | phosphatidylinositol-4-phosphate 5-kinase type 1 beta [Source:HGNC Symbol;Acc:HGNC:8995] |
| Ensembl ID | ENSG00000107242 |
| Bio databases IDs | |
| Aliases | phosphatidylinositol-4-phosphate 5-kinase type 1 beta |
| Synonyms | MSS4,phosphatidylinositol-4-phosphate 5-kinase type 1 beta,phosphatidylinositol-4-phosphate 5-kinase, type 1 beta,phosphatidylinositol-4-phosphate 5-kinase type 1 β,phosphatidylinositol-4-phosphate 5-kinase, type 1 β,PI4P5K-I[b],Pip5k1a,PIP5K1-beta,PIP5K1-β,PIP5K beta,PIP5KIbeta,PIP5K β,Pipk5b,Pipki,STM7,type I PIPKINASE beta,type I PIPKINASE β |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Phosphatidylinositol phosphate kinase (PIPK) catalytic domain family
- activation domain
- lipid kinase
- alcohol group acceptor phosphotransferase
- Phosphatidylinositol-4-phosphate 5-Kinase
- protein binding
- 1-phosphatidylinositol-3-phosphate 5-kinase
- 1-phosphatidylinositol-4-phosphate 5-kinase
Pathways
Biological processes and signaling networks where the PIP5K1B gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- PIP5K1C
- KIF20A
- APAF1
- PIP5KL1
- SNAI1
- RAC1
- LMNA
- VIRMA
- CD63
- TIRAP
disease
- cancer
- asthenozoospermia
- non-small cell lung carcinoma
- non-small cell lung cancer
- passive cutaneous anaphylaxis
- nonalcoholic fatty liver disease
- chronic kidney disease
- endometriosis
- gout
- oligozoospermia
regulated by
- EGF
- sucrose
- cisplatin
- CDC42
- TFRC
- PP1
- TGFB1
- IL4
- tetrafluoroaluminate
- deferoxamine
regulates
- AKT
- p38 MAPK
- ERK
- IL6
- IL1B
- TNF
- nitric oxide
- phosphatidylinositol 4,5-bisphosphate
- phosphatidylinositol 4-phosphate
- NFKBIA
role in cell
- number
- production in
- quantity
- phosphorylation in
- activation
- abnormal morphology
- assembly
- invasion
- formation
- function
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell surface
- perinuclear region
- cellular membrane
- Nucleus
- Plasma Membrane
- granules
- cytosol
- apical cell surfaces
- uropod
- phagosomal cups
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the PIP5K1B gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- regulation of protein kinase B signaling cascade
- phosphatidylinositol phosphorylation
- phosphatidylinositol biosynthetic process
CELLULAR COMPONENT
Where in the cell the gene product is active
- uropod
- endomembrane system
- cytosol
- plasma membrane
MOLECULAR FUNCTION
What the gene product does at the molecular level
- phosphatidylinositol kinase activity
- ATP binding
- 1-phosphatidylinositol-3-phosphate 5-kinase activity
- protein binding
- 1-phosphatidylinositol-4-phosphate 5-kinase activity
- 1-phosphatidylinositol-5-kinase activity