PF4V1
PF4V1 Gene Summary
The protein encoded by this gene is a chemokine that is highly similar to platelet factor 4. The encoded protein displays a strong antiangiogenic function and is regulated by chemokine (C-X-C motif) receptor 3. This protein also impairs tumor growth and can protect against blood-retinal barrier breakdown in diabetes patients. [provided by RefSeq, Nov 2015]
Details
| Type | Protein Coding |
| Official Symbol | PF4V1 |
| Official Name | platelet factor 4 variant 1 [Source:HGNC Symbol;Acc:HGNC:8862] |
| Ensembl ID | ENSG00000109272 |
| Bio databases IDs | |
| Aliases | platelet factor 4 variant 1 |
| Synonyms | CXCL4L1,CXCL4V1,PF4A,PF4-ALT,platelet factor 4 variant 1,SCYB4V1 |
| Species | Human, homo_sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- chemokine
- Small cytokines (intecrine/chemokine), interleukin-8 like
- protein binding
- cytokine
Pathways
Biological processes and signaling networks where the PF4V1 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- CCL11
- CCL27
- TCF12
- CCL26
- CXCR3
- TCF4
- MIF
- H2BC9
- CXCL12
- CXCL11
disease
- cancer
- epithelial cancer
- epithelial neoplasia
- lung carcinoma process
- lung cancer
- thoracic cancer
regulated by
- CXCL10
- dexamethasone
- megakaryocytes
- filgrastim
- PF4
regulates
- CXCL10
role in cell
- migration
- binding
- chemotaxis
- angiogenesis by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cell surface
- Plasma Membrane
- Golgi Apparatus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the PF4V1 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- inflammatory response
- cellular response to lipopolysaccharide
- chemokine-mediated signaling pathway
- neutrophil chemotaxis
CELLULAR COMPONENT
Where in the cell the gene product is active
- extracellular space
MOLECULAR FUNCTION
What the gene product does at the molecular level
- protein binding
- CXCR chemokine receptor binding
- heparin binding
- chemokine activity