ITGA4
ITGA4 Gene Summary
The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 4 subunit. This subunit associates with a beta 1 or beta 7 subunit to form an integrin that may play a role in cell motility and migration. This integrin is a therapeutic target for the treatment of multiple sclerosis, Crohn's disease and inflammatory bowel disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
Details
| Type | Retained Intron |
| Official Symbol | ITGA4 |
| Official Name | integrin subunit alpha 4 [Source:HGNC Symbol;Acc:HGNC:6140] |
| Ensembl ID | ENSG00000115232 |
| Bio databases IDs | |
| Aliases | integrin subunit alpha 4, antigen CD49D, alpha 4 subunit of VLA-4 receptor |
| Synonyms | Alpha4 Integrin,CD49D,IA4,integrin alpha 4,integrin subunit alpha 4,integrin subunit α 4,Integrin-α 4,Very late antigen-4 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- cell adhesion molecule binding
- paxillin-binding domain
- antigen binding
- protein binding
- fibronectin binding
- FG-GAP-like repeat
- Integrin alpha (beta-propellor repeats)
- Integrin alpha
- cytoplasmic domain
- C-X3-C chemokine binding
- integrin binding
- tail domain
- cytosolic tail domain
- FG-GAP repeat
- transmembrane receptor
- coreceptor
Pathways
Biological processes and signaling networks where the ITGA4 gene plays a role, providing insight into its function and relevance in health or disease.
- Actin Cytoskeleton Signaling
- Actin Nucleation by ARP-WASP Complex
- Agranulocyte Adhesion and Diapedesis
- Agrin Interactions at Neuromuscular Junction
- Atherosclerosis Signaling
- Caveolar-mediated Endocytosis Signaling
- Ephrin Receptor Signaling
- ERK/MAPK Signaling
- Granulocyte Adhesion and Diapedesis
- HGF Signaling
- PAK Signaling
- Paxillin Signaling
- Rac Signaling
- Regulation of Actin-based Motility by Rho
- Regulation of Cellular Mechanics by Calpain Protease
- Regulation of eIF4 and p70S6K Signaling
- RhoGDI Signaling
- Sertoli Cell-Sertoli Cell Junction Signaling
- Signaling by Rho Family GTPases
- Tec Kinase Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- RACK1
- TFRC
- ITGB1
- VCAM1
- CNBP
- ST8SIA4
- TTC9C
- SEC31A
- TRIM28
- GRB2
disease
- ulcerative colitis
- diarrhea
- septic shock
- bleeding
- sepsis
- Crohn disease
- neoplasia
- experimental autoimmune encephalomyelitis
- metastasis
- cancer
regulated by
- Ca2+
- APP
- tetradecanoylphorbol acetate
- IL1B
- lipopolysaccharide
- heavy metal
- IL4
- oleic acid
- 8-bromo-cAMP
- N-acetyl-L-cysteine
regulates
- HSP90AB1
- IL6
- TNF
- IL1B
- nitrite
- AKT
- IL2
- MMP2
- superoxide
- ERK1/2
role in cell
- expression in
- number
- production in
- adhesion
- trafficking
- formation
- proliferation
- phosphorylation in
- activation in
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- nuclear fraction
- cell surface
- cell borders
- cellular membrane
- Golgi Apparatus
- Endoplasmic Reticulum
- intercellular junctions
- membrane ruffles
- plasma membrane extracellular face
- cell membrane-lagging edges
- growth cone
- membrane processes
- cell membrane leading edge
- perikaryon
- exosomes
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the ITGA4 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- cell-matrix adhesion
- axonogenesis involved in innervation
- B cell differentiation
- negative regulation of vasoconstriction
- diapedesis
- negative regulation of protein homodimerization activity
- receptor clustering
- immune response in gut-associated lymphoid tissue
- cell-matrix adhesion involved in ameboidal cell migration
- leukocyte cell-cell adhesion
- positive regulation of T cell migration
- cell adhesion mediated by integrin
- integrin-mediated signaling pathway
- substrate adhesion-dependent cell spreading
- endodermal cell differentiation
- cell-cell adhesion mediated by integrin
- cellular response to cytokine stimulus
- positive regulation of endothelial cell apoptotic process
- leukocyte tethering or rolling
- heterotypic cell-cell adhesion
CELLULAR COMPONENT
Where in the cell the gene product is active
- growth cone
- extracellular vesicular exosome
- focal adhesion
- membrane
- external side of plasma membrane
- neuronal cell body
- alpha4-beta7 integrin complex
- integrin complex
- alpha4-beta1 integrin complex
- plasma membrane
- cell surface
MOLECULAR FUNCTION
What the gene product does at the molecular level
- coreceptor activity
- protein binding
- metal ion binding
- cell adhesion molecule binding
- fibronectin binding
- C-X3-C chemokine binding
- integrin binding