IL1R1 Gene Summary [Human]
This gene encodes a cytokine receptor that belongs to the interleukin-1 receptor family. The encoded protein is a receptor for interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor antagonist. It is an important mediator involved in many cytokine-induced immune and inflammatory responses. This gene is located in a cluster of related cytokine receptor genes on chromosome 2q12. [provided by RefSeq, Dec 2013]
Details
| Type | Protein Coding |
| Official Symbol | IL1R1 |
| Official Name | interleukin 1 receptor type 1 [Source:HGNC Symbol;Acc:HGNC:5993] |
| Ensembl ID | ENSG00000115594 |
| Bio databases IDs | |
| Aliases | interleukin 1 receptor type 1, interleukin-1 receptor, type I |
| Synonyms | CD121A, CD121b, CRMO3, D2S1473, IL1bRa, IL1R, IL-1RA, IL-1R-alpha, IL-1RI, IL-1RT-1, IL-1R-α, IL-iR, INTERLEUKIN 1 beta receptor, interleukin 1 receptor type 1, interleukin 1 receptor, type I, INTERLEUKIN 1 β receptor, P80 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human IL1R1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- protease binding
- immunoglobulin domain
- platelet-derived growth factor receptor binding
- SEFIR domain
- protein binding
- TIR domain
- interleukin-1 receptor
- interleukin-1 binding
- ionotropic glutamate receptor binding
- cytoplasmic domain
- interleukin-1, Type I, activating receptor
- Immunoglobulin like
- cytosolic tail domain
- membrane-proximal domain
- transmembrane receptor
Pathways
Biological processes and signaling networks where the IL1R1 gene in human plays a role, providing insight into its function and relevance in health or disease.
- Acute Phase Response Signaling
- Agranulocyte Adhesion and Diapedesis
- Glucocorticoid Receptor Signaling
- Granulocyte Adhesion and Diapedesis
- Hepatic Cholestasis
- Hepatic Fibrosis / Hepatic Stellate Cell Activation
- HMGB1 Signaling
- IL-1 Signaling
- IL-10 Signaling
- IL-6 Signaling
- LPS/IL-1 Mediated Inhibition of RXR Function
- LXR/RXR Activation
- Neuroinflammation Signaling Pathway
- NF-κB Signaling
- Osteoarthritis Pathway
- p38 MAPK Signaling
- PPAR Signaling
- PPARα/RXRα Activation
- Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis
- STAT3 Pathway
- Th17 Activation Pathway
- Type I Diabetes Mellitus Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- obesity
- neoplasia
- pain
- acute alcoholic hepatitis
- systemic juvenile idiopathic arthritis
- polymyositis
- adult onset Still disease
- COVID-19
- Hutchinson-Gilford progeria syndrome
role in cell
- proliferation
- apoptosis
- expression in
- swelling
- cell death
- binding
- quantity
- phosphorylation in
- production in
- growth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- cell surface
- Extracellular Space
- intracellular space
- apical compartment
- perinuclear region
- cellular membrane
- cytosol
- plasma membrane extracellular face
- apical membrane
- neurites
- dendrite initial segments
- membrane processes
- perikaryon
- axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human IL1R1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of neutrophil extravasation
- inflammatory response
- immune response
- positive regulation of interferon-gamma production
- response to interleukin-1
- regulation of inflammatory response
- positive regulation of T-helper 1 cell cytokine production
- cell surface receptor signaling pathway
- interleukin-1-mediated signaling pathway
- positive regulation of interleukin-1-mediated signaling pathway
Cellular Component
Where in the cell the gene product is active
- membrane
- external side of plasma membrane
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- NAD+ nucleosidase activity
- protein binding
- transmembrane signaling receptor activity
- platelet-derived growth factor receptor binding
- protease binding
- interleukin-1 receptor activity
- interleukin-1, Type I, activating receptor activity
- interleukin-1 binding