MYL12B
MYL12B Gene Summary
The activity of nonmuscle myosin II (see MYH9; MIM 160775) is regulated by phosphorylation of a regulatory light chain, such as MRLC2. This phosphorylation results in higher MgATPase activity and the assembly of myosin II filaments (Iwasaki et al., 2001 [PubMed 11942626]).[supplied by OMIM, Mar 2008]
Details
| Type | Protein Coding |
| Official Symbol | MYL12B |
| Official Name | myosin light chain 12B [Source:HGNC Symbol;Acc:HGNC:29827] |
| Ensembl ID | ENSG00000118680 |
| Bio databases IDs | |
| Aliases | myosin light chain 12B, myosin regulatory light chain 2 |
| Synonyms | 1500001M02Rik,MLC20,MLC-2A,MLC-B,Mlrb,MRLC2,Mylc2b,myosin light chain 12B,myosin, light chain 12B, regulatory,MYOSIN REGULATORY LIGHT CHAIN,Nrlc,RLC-B,Rmlc |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- myosin binding
- EF-hand, calcium binding motif
- EF-hand domain
- EF hand
- EF-hand domain pair
- EF-hand, calcium binding motif, found in parvalbumin-like EF-hand family
- protein binding
Pathways
Biological processes and signaling networks where the MYL12B gene plays a role, providing insight into its function and relevance in health or disease.
- Actin Cytoskeleton Signaling
- Apelin Cardiomyocyte Signaling Pathway
- Axonal Guidance Signaling
- Cardiac Hypertrophy Signaling
- Cdc42 Signaling
- Cellular Effects of Sildenafil (Viagra)
- CXCR4 Signaling
- Ephrin A Signaling
- Epithelial Adherens Junction Signaling
- Estrogen Receptor Signaling
- G-Protein Coupled Receptor Signaling
- Gα12/13 Signaling
- IL-8 Signaling
- Integrin Signaling
- PAK Signaling
- Phagosome Formation
- Regulation of Actin-based Motility by Rho
- RhoA Signaling
- RhoGDI Signaling
- Signaling by Rho Family GTPases
- Thrombin Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- GABRA1
- AR
- SLC6A4
- ANLN
- PLEKHA4
- DDX39B
- ESR2
- EED
- DDX39A
- LGALS3
disease
- chronic sinusitis
- aortic valve calcification
regulated by
- AGT
- TGFB1
- tetradecanoylphorbol acetate
- Immunoglobulin
- U0126
- LDL
- cyclic AMP
- IL23
- VHL
- Mlck
regulates
- MYL12B
role in cell
- migration
- quantity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- apical compartment
- peripheral lamellae
- cell cortex
- Nucleus
- cytosol
- Z line
- actin stress fibers
- membrane rafts
- brush border
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the MYL12B gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- regulation of cell shape
CELLULAR COMPONENT
Where in the cell the gene product is active
- Z disc
- extracellular vesicular exosome
- apical part of cell
- brush border
- cytoplasm
- cell cortex
- stress fiber
- myosin II complex
- cytosol
- myofibril
MOLECULAR FUNCTION
What the gene product does at the molecular level
- protein binding
- calcium ion binding
- myosin heavy chain binding