GNA13
GNA13 Gene Summary
Predicted to enable D5 dopamine receptor binding activity; G-protein beta/gamma-subunit complex binding activity; and GTPase activity. Predicted to be involved in several processes, including Rho protein signal transduction; activation of phospholipase D activity; and multicellular organism aging. Predicted to act upstream of or within several processes, including branching involved in blood vessel morphogenesis; negative regulation of vascular associated smooth muscle cell migration; and negative regulation of vascular associated smooth muscle cell proliferation. Located in cytosol and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | GNA13 |
| Official Name | G protein subunit alpha 13 [Source:HGNC Symbol;Acc:HGNC:4381] |
| Ensembl ID | ENSG00000120063 |
| Bio databases IDs | |
| Aliases | G protein subunit alpha 13 |
| Synonyms | AU024132,G13,GALPHA13,G protein alpha 13,G protein subunit alpha 13,G protein subunit α 13,G protein α 13,guanine nucleotide binding protein, alpha 13,guanine nucleotide binding protein, α 13,G α 13,HG1N |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G protein alpha subunit
- effector loop
- GTPase domain
- guanyl-nucleotide exchange factor
- G-protein-coupled receptor binding
- small monomeric GTPase
- GTPase
- G-protein alpha subunit
- enzyme
- protein binding
- P-loop containing Nucleoside Triphosphate Hydrolases
Pathways
Biological processes and signaling networks where the GNA13 gene plays a role, providing insight into its function and relevance in health or disease.
- Actin Cytoskeleton Signaling
- AMPK Signaling
- Androgen Signaling
- Apelin Endothelial Signaling Pathway
- Apelin Muscle Signaling Pathway
- Cardiac β-adrenergic Signaling
- CCR3 Signaling in Eosinophils
- CCR5 Signaling in Macrophages
- Cholecystokinin/Gastrin-mediated Signaling
- CXCR4 Signaling
- Endocannabinoid Cancer Inhibition Pathway
- Endothelin-1 Signaling
- Ephrin B Signaling
- Ephrin Receptor Signaling
- ERK5 Signaling
- fMLP Signaling in Neutrophils
- G Beta Gamma Signaling
- Gα12/13 Signaling
- Gαq Signaling
- IL-1 Signaling
- IL-8 Signaling
- Molecular Mechanisms of Cancer
- Protein Kinase A Signaling
- Relaxin Signaling
- RHOA Signaling
- Sperm Motility
- Thrombin Signaling
- α-Adrenergic Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- RAB21
- INPPL1
- GNAS
- GNB3
- GNAO1
- FLNC
- PRKAR2A
- NRAS
- GNB1
- GNAI2
disease
- neoplasia
- cancer
- IG-MYC translocation positive Burkitt lymphoma
- B-cell non-Hodgkin disease
- mature B-cell neoplasia
- breast cancer
- classical Hodgkin lymphoma
- classic Hodgkin disease
- duodenal-type follicular lymphoma
- follicular non-Hodgkin disease
regulated by
- Ca2+
- KRAS
- IFNG
- TSHR
- TSH
- tetrafluoroaluminate
- ITGB3
- epoprostenol
- sphingosine-1-phosphate
- TGFB1
regulates
- AKT
- ERK
- CXCL8
- p38 MAPK
- JNK
- NFE2L2
- AKT1
- MAPK8
- reporter gene
- Ca2+
role in cell
- growth
- migration
- invasion by
- apoptosis
- proliferation
- expression in
- activation in
- quantity
- phosphorylation in
- chemotaxis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- plasma membrane fraction
- membrane fraction
- detergent resistant lipid raft fraction
- Cytoplasm
- postsynaptic region
- cellular membrane
- Nucleus
- Mitochondria
- cytosol
- brush border
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the GNA13 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- regulation of cell shape
- G-protein coupled receptor signaling pathway
- signal transduction
- adenylate cyclase-modulating G-protein coupled receptor signaling pathway
- adenylate cyclase-activating G-protein coupled receptor signaling pathway
- Rho protein signal transduction
- regulation of blood pressure
- elevation of cytosolic calcium ion concentration
- in utero embryonic development
- patterning of blood vessels
- regulation of small GTPase mediated signal transduction
- cell differentiation
- platelet activation
- regulation of fibroblast migration
CELLULAR COMPONENT
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- heterotrimeric G-protein complex
- brush border membrane
- focal adhesion
- cytoplasm
- melanosome
- membrane
- cytosol
- plasma membrane
MOLECULAR FUNCTION
What the gene product does at the molecular level
- GTP binding
- protein binding
- metal ion binding
- GTPase activity
- guanyl-nucleotide exchange factor activity
- small monomeric GTPase activity
- G-protein beta/gamma-subunit complex binding
- D5 dopamine receptor binding