CCR2
CCR2 Gene Summary
The protein encoded by this gene is a receptor for monocyte chemoattractant protein-1, a chemokine which specifically mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. The encoded protein mediates agonist-dependent calcium mobilization and inhibition of adenylyl cyclase. This protein can also be a coreceptor with CD4 for HIV-1 infection. This gene is located in the chemokine receptor gene cluster region of chromosome 3. [provided by RefSeq, Aug 2017]
Details
| Type | Processed Transcript |
| Official Symbol | CCR2 |
| Official Name | C-C motif chemokine receptor 2 [Source:HGNC Symbol;Acc:HGNC:1603] |
| Ensembl ID | ENSG00000121807 |
| Bio databases IDs | |
| Aliases | C-C motif chemokine receptor 2 |
| Synonyms | CC-CKR-2,C-C motif chemokine receptor 2,Ccr2a,Ccr2b,CD192,CHEMOKINE CC2 receptor,CKR2,CKR2A,CKR2B,CMKBR2,MCP-1-R,mJe-r,PCLUD |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- extracellular domain
- Cholecystokinin A receptor, N-terminal
- cytokine binding
- CCR chemokine receptor binding
- chemokine receptor binding domain
- protein binding
- identical protein binding
- seven-transmembrane G protein-coupled receptor superfamily
- phosphorylation site
- C-C chemokine receptor
- chemokine receptor
- C-C chemokine binding
- 7 transmembrane receptor (rhodopsin family)
- tail domain
- transmembrane receptor
Pathways
Biological processes and signaling networks where the CCR2 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- CXCR4
- CCL7
- CCL2
- CCR5
- CCL13
- POTEE
- Ccl12
- RTN3
- chemokine
- ERGIC3
disease
- neoplasia
- metastasis
- cancer
- weight gain
- fibrosis
- epithelial cancer
- epithelial neoplasia
- prostate cancer
- abdominal cancer
- urogenital cancer
regulated by
- EPAS1
- TGFB1
- Pertussis toxin
- ERBB2
- bone marrow-derived macrophages
- insulin
- NFAT5
- acetaminophen
- CCL2
- NFkB (complex)
regulates
- Ccl3
- CCR1
- IFNG
- ERK1/2
- Ccl12
- Ccl7
- CCL2
- VEGF
- CD40
- TNF
role in cell
- apoptosis
- production in
- expression in
- activation in
- recruitment
- number
- proliferation
- density
- phosphorylation in
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- fibrillar center
- Cytoplasm
- cell surface
- Extracellular Space
- apical compartment
- perinuclear region
- cellular membrane
- filamentous network
- plasma membrane extracellular face
- cell membrane leading edge
- perikaryon
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the CCR2 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- negative regulation of adenylate cyclase activity
- negative regulation of angiogenesis
- hemopoiesis
- response to wounding
- JAK-STAT cascade
- cell chemotaxis
- chemotaxis
- positive regulation of monocyte extravasation
- positive regulation of T cell activation
- inflammatory response
- immune response
- positive regulation of alpha-beta T cell proliferation
- cytokine-mediated signaling pathway
- humoral immune response
- positive regulation of interferon-gamma production
- positive regulation of tumor necrosis factor production
- positive regulation of CD8-positive, alpha-beta T cell extravasation
- positive regulation of synaptic transmission, glutamatergic
- calcium-mediated signaling
- positive regulation of hematopoietic stem cell migration
- regulation of vascular endothelial growth factor production
- positive regulation of thymocyte migration
- positive regulation of interleukin-2 production
- cellular homeostasis
- monocyte extravasation
- positive regulation of monocyte chemotaxis
- positive regulation of immune complex clearance by monocytes and macrophages
- positive regulation of inflammatory response
- negative regulation of eosinophil degranulation
- elevation of cytosolic calcium ion concentration
- cellular calcium ion homeostasis
- regulation of T cell differentiation
- cellular defense response
- blood vessel remodeling
- T-helper 17 cell chemotaxis
- homeostasis of number of cells within a tissue
- monocyte chemotaxis
- regulation of T cell cytokine production
- chemokine-mediated signaling pathway
- dendritic cell chemotaxis
- positive regulation of T cell chemotaxis
- positive regulation of T-helper 1 type immune response
- positive regulation of astrocyte chemotaxis
- sensory perception of pain
- regulation of inflammatory response
- negative regulation of type 2 immune response
CELLULAR COMPONENT
Where in the cell the gene product is active
- dendrite
- perinuclear region of cytoplasm
- cytoplasm
- membrane
- external side of plasma membrane
- cytosol
- neuronal cell body
- perikaryon
- plasma membrane
- fibrillar center
MOLECULAR FUNCTION
What the gene product does at the molecular level
- C-C chemokine binding
- identical protein binding
- protein binding
- chemokine (C-C motif) ligand 12 binding
- chemokine (C-C motif) ligand 7 binding
- CCR2 chemokine receptor binding
- C-C chemokine receptor activity
- chemokine (C-C motif) ligand 2 binding
- chemokine receptor activity