CXCL6
CXCL6 Gene Summary
The protein encoded by this gene is a member CXC chemokine family. The encoded protein is a chemotactic for neutrophil granulocytes and has antibacterial action against gram-negative and gram-positive bacteria. This gene and other members of the CXC chemokine gene family form a gene cluster in a region of chromosome 4q. [provided by RefSeq, Jun 2020]
Details
| Type | Protein Coding |
| Official Symbol | CXCL6 |
| Official Name | C-X-C motif chemokine ligand 6 [Source:HGNC Symbol;Acc:HGNC:10643] |
| Ensembl ID | ENSG00000124875 |
| Bio databases IDs | |
| Aliases | C-X-C motif chemokine ligand 6, granulocyte chemotactic protein 2 |
| Synonyms | Chemokine alpha 3,Chemokine α 3,CKA-3,Cxcl5,C-X-C motif chemokine ligand 6,GCP-2,Scyb5,SCYB6 |
| Species | Human, homo_sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- chemokine
- Small cytokines (intecrine/chemokine), interleukin-8 like
- protein binding
- cytokine
Pathways
Biological processes and signaling networks where the CXCL6 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- CXCL12
- MMP9
- PF4
- LRCH3
- RRP36
- CXCR2
- PPP1R12A
- CCL8
- CCL7
- CCL11
disease
- epithelial cancer
- cholangiocarcinoma cancer
- metastasis
- COVID-19
- prostate cancer
- gastric cancer
- organismal death
- diabetic nephropathy
- osteoarthritis
- adenoid cystic carcinoma
regulated by
- TNF
- lipopolysaccharide
- IL10
- oleic acid
- palmitic acid
- doxorubicin
- STING1
- IL1B
- KLF5
- MMP12
regulates
- CXCR2
- HAMP
- GNAO1
- GNAI1
- GNAI3
- GNA15
- CCL18
- GNAI2
role in cell
- binding
- activation in
- activation
- invasion
- development
- chemotaxis
- response
- attraction
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cell surface
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the CXCL6 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- neutrophil activation
- signal transduction
- cell-cell signaling
- defense response to bacterium
- chemotaxis
- inflammatory response
- leukocyte homeostasis
- cellular response to lipopolysaccharide
- chemokine-mediated signaling pathway
- regulation of neutrophil mediated killing of gram-negative bacterium
- neutrophil chemotaxis
- regulation of chemokine production
CELLULAR COMPONENT
Where in the cell the gene product is active
- extracellular space
- extracellular region
MOLECULAR FUNCTION
What the gene product does at the molecular level
- protein binding
- CXCR chemokine receptor binding
- heparin binding
- chemokine activity