ELK1
ELK1 Gene Summary
This gene is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum response element in the promoter of the c-fos proto-oncogene. The protein encoded by this gene is a nuclear target for the ras-raf-MAPK signaling cascade. This gene produces multiple isoforms by using alternative translational start codons and by alternative splicing. Related pseudogenes have been identified on chromosomes 7 and 14. [provided by RefSeq, Mar 2012]
Details
| Type | Protein Coding |
| Official Symbol | ELK1 |
| Official Name | ETS transcription factor ELK1 [Source:HGNC Symbol;Acc:HGNC:3321] |
| Ensembl ID | ENSG00000126767 |
| Bio databases IDs | |
| Aliases | ETS transcription factor ELK1 |
| Synonyms | ELK,ELK1, member of ETS oncogene family,ETS transcription factor ELK1,p62TCF,RGD:2549,TCF/ELK |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- A-box
- transcription regulator
- transcription co-activator
- Sumoylation motif
- C-box domain
- transcription activation domain
- transcription factor binding
- chromatin binding
- fxfp sequence
- docking domain
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- Ets-domain
- D-Box
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- activation domain
- nuclear export signal
- DNA binding domain
- nucleic acid binding
- MAPK binding site
- Sin3 binding domain
- protein binding
- sequence-specific DNA binding
- kinase regulatory domain
- phosphorylation site
- transcription repression domain
- binding protein
- double-stranded DNA binding
- TCF D domain
- hinge domain
- Box B domain
- CAD domain
- transcription factor activity
- SRF binding domain
Pathways
Biological processes and signaling networks where the ELK1 gene plays a role, providing insight into its function and relevance in health or disease.
- Antiproliferative Role of Somatostatin Receptor 2
- April Mediated Signaling
- B Cell Activating Factor Signaling
- Corticotropin Releasing Hormone Signaling
- CXCR4 Signaling
- EGF Signaling
- Endometrial Cancer Signaling
- Estrogen-Dependent Breast Cancer Signaling
- FLT3 Signaling in Hematopoietic Progenitor Cells
- fMLP Signaling in Neutrophils
- Glucocorticoid Receptor Signaling
- GM-CSF Signaling
- Growth Hormone Signaling
- HER-2 Signaling in Breast Cancer
- HGF Signaling
- IGF-1 Signaling
- IL-3 Signaling
- IL-6 Signaling
- Neuropathic Pain Signaling in Dorsal Horn Neurons
- Oncostatin M Signaling
- PDGF Signaling
- PEDF Signaling
- Rac Signaling
- RANK Signaling in Osteoclasts
- Regulation of IL-2 Expression in Activated and Anergic T Lymphocytes
- Sertoli Cell-Sertoli Cell Junction Signaling
- Thyroid Cancer Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- AR
- ELK1
- BAG2
- TCF4
- MAPK3
- ITGB6
- HIF1A
- SLC39A7
- UBE2I
- GRN
disease
- neoplasia
- Alzheimer disease
- schizophrenia
- glioblastoma
- glioblastoma cancer
- idiopathic fetal growth restriction
- idiopathic pulmonary fibrosis
- thyroid cancer
- bleomycin-induced pulmonary fibrosis
- morbid obesity
regulated by
- ERK1/2
- JNK
- lipopolysaccharide
- ITSN1
- EGF
- IGF
- BDNF
- MAPK14
- AKT1
- 2-deoxyglucose
regulates
- histone H3
- DNA promoter
- DNA endogenous promoter
- ERK
- D-glucose
- luciferase reporter gene
- synthetic promoter
- JUN
- SLC2A1
- ZFP36
role in cell
- expression in
- cell death
- morphology
- growth
- phosphorylation in
- apoptosis
- binding in
- activation in
- proliferation
- cell viability
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- cytosol
- mitochondrial membrane
- nucleoplasm
- synaptosomes
- chromatin
- perikaryon
- axons
- dendrites
- axon terminals
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the ELK1 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- positive regulation of transcription from RNA polymerase II promoter
- response to light stimulus
- regulation of transcription from RNA polymerase II promoter
- cellular response to testosterone stimulus
- response to ethanol
- cellular response to gamma radiation
- positive regulation of transcription, DNA-dependent
- liver development
- cell differentiation
- gene expression
- response to fibroblast growth factor stimulus
- lung development
CELLULAR COMPONENT
Where in the cell the gene product is active
- dendrite
- nucleus
- mitochondrial membrane
- neuronal cell body
- chromatin
- axon terminus
- nucleoplasm
MOLECULAR FUNCTION
What the gene product does at the molecular level
- sequence-specific DNA binding transcription factor activity
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- ligand-dependent nuclear receptor transcription coactivator activity
- transcription regulatory region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- chromatin binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity