GNG11
GNG11 Gene Summary
This gene is a member of the guanine nucleotide-binding protein (G protein) gamma family and encodes a lipid-anchored, cell membrane protein. As a member of the heterotrimeric G protein complex, this protein plays a role in this transmembrane signaling system. This protein is also subject to carboxyl-terminal processing. Decreased expression of this gene is associated with splenic marginal zone lymphomas. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | GNG11 |
| Official Name | G protein subunit gamma 11 [Source:HGNC Symbol;Acc:HGNC:4403] |
| Ensembl ID | ENSG00000127920 |
| Bio databases IDs | |
| Aliases | G protein subunit gamma 11, G protein gamma-11 subunit, guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-11 subunit |
| Synonyms | 0610037B21Rik,GNGT11,G protein gamma 11 subunit,G protein subunit gamma 11,G protein subunit γ 11,G protein γ 11 subunit,GUANINE NUCLEOTIDE binding protein 11,guanine nucleotide binding protein (G protein), gamma 11,guanine nucleotide binding protein (G protein), γ 11,HG3H1,LOC100912034 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GGL
- GTPase
- protein binding
- GGL domain
Pathways
Biological processes and signaling networks where the GNG11 gene plays a role, providing insight into its function and relevance in health or disease.
- AMPK Signaling
- Androgen Signaling
- Antiproliferative Role of Somatostatin Receptor 2
- Apelin Endothelial Signaling Pathway
- Apelin Muscle Signaling Pathway
- Cardiac β-adrenergic Signaling
- CCR3 Signaling in Eosinophils
- CCR5 Signaling in Macrophages
- CXCR4 Signaling
- Endocannabinoid Developing Neuron Pathway
- Ephrin B Signaling
- Ephrin Receptor Signaling
- fMLP Signaling in Neutrophils
- G Beta Gamma Signaling
- Glutamate Receptor Signaling
- Gαq Signaling
- IL-1 Signaling
- IL-8 Signaling
- Molecular Mechanisms of Cancer
- P2Y Purinergic Receptor Signaling Pathway
- Protein Kinase A Signaling
- Relaxin Signaling
- RhoGDI Signaling
- Sperm Motility
- Thrombin Signaling
- α-Adrenergic Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- AMOTL2
- MEOX2
- SMURF1
- GNB1
- PDCL
- FOS
- CEP44
- ZHX1
- GNB4
- GNAI3
disease
- uterine leiomyoma
- leiomyomatosis
- essential thrombocythemia
- pemphigus vulgaris
regulated by
- GW3965
- dexamethasone
- thioacetamide
- halofuginone
- IFNG
- calcitriol
- PPRC1
- LDHA
- CRYBA1
- TMPRSS2-ERG
regulates
- HAMP
role in cell
- fragmentation
- fragmentation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- Golgi Apparatus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the GNG11 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- G-protein coupled receptor signaling pathway
- signal transduction
CELLULAR COMPONENT
Where in the cell the gene product is active
- heterotrimeric G-protein complex
- plasma membrane
MOLECULAR FUNCTION
What the gene product does at the molecular level
- protein binding
- G-protein beta-subunit binding
- GTPase activity