GNAI1
GNAI1 Gene Summary
Guanine nucleotide binding proteins are heterotrimeric signal-transducing molecules consisting of alpha, beta, and gamma subunits. The alpha subunit binds guanine nucleotide, can hydrolyze GTP, and can interact with other proteins. The protein encoded by this gene represents the alpha subunit of an inhibitory complex. The encoded protein is part of a complex that responds to beta-adrenergic signals by inhibiting adenylate cyclase. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Details
| Type | Processed Transcript |
| Official Symbol | GNAI1 |
| Official Name | G protein subunit alpha i1 [Source:HGNC Symbol;Acc:HGNC:4384] |
| Ensembl ID | ENSG00000127955 |
| Bio databases IDs | |
| Aliases | G protein subunit alpha i1, Gi1 protein alpha subunit, Guanine nucleotide-binding protein G(i) subunit alpha-1 |
| Synonyms | BPGTPB,G alpha I1,Gi,Gi1 alpha-subunit,Gi1 α-subunit,Gialpha1,G protein subunit alpha i1,G protein subunit α i1,G protein α I1,G α I1,HG1B,NEDHISB |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G protein alpha subunit
- palmitoylation site
- small monomeric GTPase
- enzyme inhibitor activity
- G-protein-coupled receptor binding
- alpha helix
- GTPase
- enzyme
- enzyme regulator activity
- protein binding
- magnesium ion binding
- GTP binding
- GTPase domain
- GDP binding
- myristoylation sequence
- G-protein alpha subunit
- P-loop containing Nucleoside Triphosphate Hydrolases
Pathways
Biological processes and signaling networks where the GNAI1 gene plays a role, providing insight into its function and relevance in health or disease.
- AMPK Signaling
- Apelin Adipocyte Signaling Pathway
- Apelin Cardiomyocyte Signaling Pathway
- Apelin Endothelial Signaling Pathway
- Apelin Muscle Signaling Pathway
- CCR3 Signaling in Eosinophils
- Chemokine Signaling
- Corticotropin Releasing Hormone Signaling
- CXCR4 Signaling
- Endocannabinoid Cancer Inhibition Pathway
- Endocannabinoid Developing Neuron Pathway
- Endothelin-1 Signaling
- Ephrin B Signaling
- Ephrin Receptor Signaling
- fMLP Signaling in Neutrophils
- G Beta Gamma Signaling
- Gαq Signaling
- IL-1 Signaling
- P2Y Purinergic Receptor Signaling Pathway
- Protein Kinase A Signaling
- Relaxin Signaling
- RhoGDI Signaling
- Role of PI3K/AKT Signaling in the Pathogenesis of Influenza
- Sperm Motility
- Thrombin Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- GABRA1
- EGFR
- KIT
- GPSM1
- DLG4
- DCTN3
- OPRD1
- RGS4
- NMRAL1
- COX15
disease
- Parkinson disease
- cancer
- T-cell non-Hodgkin disease
- asthma
- neurodevelopmental disorder with hypotonia, impaired speech, and behavioral abnormalities
- hereditary disorder
- schizophrenia
- mature T-cell neoplasia
- central nervous system cancer
- brain cancer
regulated by
- 8-bromo-cAMP
- lithium
- TNF
- budesonide
- ethanol
- RIC8A
- TP53
- cycloheximide
- PPBP
- cholesterol
regulates
- TNF
- IL6
- JNK
- ERK
- MAPK8
- KIT
- TRPM8
- PRL
- D-glucose
- ERK1/2
role in cell
- phosphorylation in
- expression in
- cell death
- activation in
- proliferation
- migration
- aggregation
- cytokinesis
- tubulation
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- soluble fraction
- detergent-soluble membrane fractions
- membrane fraction
- detergent resistant lipid raft fraction
- glutaminergic synapse
- caveolae-derived endocytic vesicles
- Cytoplasm
- cell surface
- cell periphery
- intracellular space
- perinuclear region
- postsynaptic region
- cellular membrane
- cell cortex
- Nucleus
- basal bodies
- centrosome
- Golgi Apparatus
- midbody
- cytosol
- nucleoplasm
- nucleoli
- membrane rafts
- perikaryon
- clathrin-coated vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the GNAI1 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
- cell division
- G-protein coupled receptor signaling pathway
- regulation of cAMP-mediated signaling
- adenylate cyclase-modulating G-protein coupled receptor signaling pathway
- response to peptide hormone stimulus
- regulation of mitotic spindle organization
CELLULAR COMPONENT
Where in the cell the gene product is active
- centrosome
- heterotrimeric G-protein complex
- extracellular vesicular exosome
- cytoplasm
- cell cortex
- midbody
- nucleolus
- lysosomal membrane
- plasma membrane
- nucleoplasm
MOLECULAR FUNCTION
What the gene product does at the molecular level
- magnesium ion binding
- GTP binding
- G-protein coupled receptor binding
- protein binding
- GTPase activity
- D2 dopamine receptor binding
- GDP binding
- G-protein beta/gamma-subunit complex binding
- G-protein coupled serotonin receptor binding