ITGAV
ITGAV Gene Summary
The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha V subunit. This subunit associates with beta 1, beta 3, beta 5, beta 6 and beta 8 subunits. The heterodimer consisting of alpha V and beta 3 subunits is also known as the vitronectin receptor. This integrin may regulate angiogenesis and cancer progression. Alternative splicing results in multiple transcript variants. Note that the integrin alpha 5 and integrin alpha V subunits are encoded by distinct genes. [provided by RefSeq, Oct 2015]
Details
| Type | Protein Coding |
| Official Symbol | ITGAV |
| Official Name | integrin subunit alpha V [Source:HGNC Symbol;Acc:HGNC:6150] |
| Ensembl ID | ENSG00000138448 |
| Bio databases IDs | |
| Aliases | integrin subunit alpha V |
| Synonyms | 1110004F14RIK,2610028E01Rik,alpha V,CD51,D430040G12RIK,integrin alpha V,integrin subunit alpha V,integrin subunit α V,Integrin α V,MSK8,VNRA,VTNR,α V |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- protease binding
- extracellular matrix binding
- protein kinase C binding
- insulin-like growth factor binding
- protein binding
- receptor binding
- TGFbeta binding
- fibronectin binding
- FG-GAP-like repeat
- Integrin alpha (beta-propellor repeats)
- Integrin alpha
- cytoplasmic domain
- fibroblast growth factor binding
- C-X3-C chemokine binding
- integrin binding
- intracellular domain
- collagen binding
- cytosolic tail domain
- FG-GAP repeat
- transmembrane receptor
- growth factor binding
- coreceptor
Pathways
Biological processes and signaling networks where the ITGAV gene plays a role, providing insight into its function and relevance in health or disease.
- Actin Cytoskeleton Signaling
- Actin Nucleation by ARP-WASP Complex
- Caveolar-mediated Endocytosis Signaling
- Ephrin Receptor Signaling
- ERK/MAPK Signaling
- Glioma Invasiveness Signaling
- HGF Signaling
- Integrin Signaling
- NF-κB Activation by Viruses
- PAK Signaling
- Paxillin Signaling
- Rac Signaling
- Regulation of Actin-based Motility by Rho
- Regulation of Cellular Mechanics by Calpain Protease
- Regulation of eIF4 and p70S6K Signaling
- RhoGDI Signaling
- Role of Tissue Factor in Cancer
- Sertoli Cell-Sertoli Cell Junction Signaling
- Signaling by Rho Family GTPases
- Tec Kinase Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- INSR
- IGF1R
- STAT3
- ITGB3
- ICAM4
- COL4A3
- PRNP
- RHOV
- SPP1
- PDGFRB
disease
- diabetes mellitus
- osteolysis
- severe COVID-19
- Alport syndrome
- membranous glomerulonephritis
- plasma cell myeloma
- hyperzincemia and hypercalprotectinemia autoinflammatory syndrome
- metastasis
- growth failure
- tumorigenesis
regulated by
- EPAS1
- N-[N-(3,5-difluorophenacetyl-L-Ala)]-S-phenylglycine t-butyl ester
- CCND1
- CG
- PD98059
- TGF beta
- FOXM1
- lipopolysaccharide
- KLF11
- MLL-AF9 cells
regulates
- JUN
- FOS
- Ca2+
- BCL2L1
- cyclic AMP
- lipid
- CDKN1B
- focal adhesion kinase
- CDK1
- VEGF
role in cell
- binding
- cell death
- activity
- formation
- expression in
- survival
- proliferation
- activation
- migration
- activation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- Cytoplasm
- cell surface
- cell borders
- cellular membrane
- focal adhesions
- Nucleus
- cytoplasmic particles
- specific granule membrane
- cytosol
- apical cell surfaces
- basolateral cell surfaces
- membrane ruffles
- plasma membrane extracellular face
- basolateral membrane
- cytoplasmic vesicles
- microvilli
- filopodia
- exosomes
- phagosomes
- plasma
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the ITGAV gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- viral entry into host cell
- negative chemotaxis
- positive regulation of cell proliferation
- cell adhesion
- positive regulation of cell adhesion
- extrinsic apoptotic signaling pathway in absence of ligand
- vasculogenesis
- integrin-mediated signaling pathway
- negative regulation of entry of bacterium into host cell
- angiogenesis
- calcium ion transmembrane transport
- substrate adhesion-dependent cell spreading
- cell migration
- wound healing, spreading of epidermal cells
- negative regulation of lipid transport
- positive regulation of osteoblast proliferation
- cell-matrix adhesion
- apolipoprotein A-I-mediated signaling pathway
- symbiont entry into host cell forming a symbiont-containing vacuole
- apoptotic cell clearance
- elevation of cytosolic calcium ion concentration
- ERK1 and ERK2 cascade
- cell adhesion mediated by integrin
- positive regulation of small GTPase mediated signal transduction
- endodermal cell differentiation
- negative regulation of lipoprotein metabolic process
- negative regulation of extrinsic apoptotic signaling pathway
- negative regulation of macrophage derived foam cell differentiation
- negative regulation of lipid storage
- heterotypic cell-cell adhesion
- cell-substrate adhesion
- transforming growth factor beta production
- regulation of phagocytosis
- positive regulation of cell migration
CELLULAR COMPONENT
Where in the cell the gene product is active
- alphav-beta5 integrin complex
- alphav-beta3 integrin complex
- alphav-beta1 integrin complex
- external side of plasma membrane
- phagocytic vesicle
- integrin complex
- plasma membrane
- cell surface
- filopodium membrane
- microvillus membrane
- extracellular vesicular exosome
- focal adhesion
- membrane
- alphav-beta3 integrin-PKCalpha complex
- alphav-beta3 integrin-IGF-1-IGF1R complex
- cytosol
- ruffle membrane
- alphav-beta8 integrin complex
- alphav-beta3 integrin-HMGB1 complex
- alphav-beta6 integrin complex
- lamellipodium membrane
- specific granule membrane
MOLECULAR FUNCTION
What the gene product does at the molecular level
- protein kinase C binding
- coreceptor activity
- neuregulin binding
- protease binding
- integrin binding
- voltage-gated calcium channel activity
- transforming growth factor beta binding
- extracellular matrix binding
- protein binding
- metal ion binding
- opsonin binding
- C-X3-C chemokine binding
- fibronectin binding
- fibroblast growth factor binding
- viral receptor activity
- insulin-like growth factor I binding