CXCL9
CXCL9 Gene Summary
This antimicrobial gene is part of a chemokine superfamily that encodes secreted proteins involved in immunoregulatory and inflammatory processes. The protein encoded is thought to be involved in T cell trafficking. The encoded protein binds to C-X-C motif chemokine 3 and is a chemoattractant for lymphocytes but not for neutrophils. [provided by RefSeq, Aug 2020]
Details
| Type | Protein Coding |
| Official Symbol | CXCL9 |
| Official Name | C-X-C motif chemokine ligand 9 [Source:HGNC Symbol;Acc:HGNC:7098] |
| Ensembl ID | ENSG00000138755 |
| Bio databases IDs | |
| Aliases | C-X-C motif chemokine ligand 9 |
| Synonyms | BB139920,CMK,crg-10,C-X-C motif chemokine ligand 9,Humig,MIG,monokine induced by IFN-γ,MuMIG,SCYB9 |
| Species | Human, homo_sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- chemokine
- Small cytokines (intecrine/chemokine), interleukin-8 like
- CXCR3 chemokine receptor binding
- protein binding
- cytokine
Pathways
Biological processes and signaling networks where the CXCL9 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- SFTPC
- CXCR3
- cardiolipin
- RBPJ
- IRF8
- GJB1
- TMEM106C
- CLDN7
- CCL11
- UBE2O
disease
- neoplasia
- glioblastoma
- cancer
- Parkinson disease
- rheumatoid arthritis
- psoriasis
- breast cancer
- cutaneous melanoma cancer
- skin cancer
- melanoma cancer
regulated by
- HFF cells
- PTEN
- MYC
- ethanol
- FCGR1A
- Pertussis toxin
- HFE
- Klebsiella pneumoniae serotype 2 strain ATCC 43816
- Mycobacterium avium strain 2447
- Influenza A virus (A/WSN/1933(H1N1))
regulates
- IgG
- Ca2+
- CCL2
- ICAM1
- CXCL8
- IFNB1
- IL10
- CXCR3
- ERK1/2
- p38 MAPK
role in cell
- expression in
- cellular infiltration by
- proliferation
- migration
- adhesion
- recruitment
- activation
- phosphorylation in
- activation in
- cellular infiltration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- cell surface
- intracellular space
- plasma membrane extracellular face
- extracellular matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the CXCL9 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- G-protein coupled receptor signaling pathway
- signal transduction
- cell-cell signaling
- positive regulation of myoblast differentiation
- adenylate cyclase-activating G-protein coupled receptor signaling pathway
- positive regulation of release of sequestered calcium ion into cytosol
- defense response
- regulation of cell proliferation
- cellular defense response
- chemotaxis
- inflammatory response
- cellular response to lipopolysaccharide
- chemokine-mediated signaling pathway
- neutrophil chemotaxis
- defense response to virus
CELLULAR COMPONENT
Where in the cell the gene product is active
- extracellular space
- external side of plasma membrane
- extracellular region
MOLECULAR FUNCTION
What the gene product does at the molecular level
- protein binding
- CXCR chemokine receptor binding
- CXCR3 chemokine receptor binding
- cytokine activity
- chemokine activity