RHOF
RHOF Gene Summary
Predicted to enable GTP binding activity; GTPase activity; and protein kinase binding activity. Involved in actin filament organization. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | RHOF |
| Official Name | ras homolog family member F, filopodia associated [Source:HGNC Symbol;Acc:HGNC:15703] |
| Ensembl ID | ENSG00000139725 |
| Bio databases IDs | |
| Aliases | ras homolog family member F, filopodia associated, rho in filopodia |
| Synonyms | ARHF,FLJ20247,Ifld1,ras homolog family member F, filopodia associated,ras homolog family member F (in filopodia),RIF |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- small GTP-binding protein domain
- Small GTPase of the Ras superfamily (ill-defined subfamily)
- Ras family
- guanyl-nucleotide exchange factor
- Rab subfamily of small GTPases
- enzyme
- Ras of Complex, Roc, domain of DAPkinase
- Rho (Ras homology) subfamily of Ras-like small GTPases
- P-loop containing Nucleoside Triphosphate Hydrolases
- Ras subfamily of RAS small GTPases
Pathways
Biological processes and signaling networks where the RHOF gene plays a role, providing insight into its function and relevance in health or disease.
- Actin Nucleation by ARP-WASP Complex
- Cholecystokinin/Gastrin-mediated Signaling
- CXCR4 Signaling
- Germ Cell-Sertoli Cell Junction Signaling
- Glioblastoma Multiforme Signaling
- Glioma Invasiveness Signaling
- Gαq Signaling
- HMGB1 Signaling
- IL-8 Signaling
- ILK Signaling
- Integrin Signaling
- mTOR Signaling
- Production of Nitric Oxide and Reactive Oxygen Species in Macrophages
- Regulation of Actin-based Motility by Rho
- RhoGDI Signaling
- Semaphorin Signaling in Neurons
- Serotonin Receptor Signaling
- Signaling by Rho Family GTPases
- Sphingosine-1-phosphate Signaling
- Tec Kinase Signaling
- Thrombin Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- ESR2
- EGFR
- SLC7A11
- ITCH
- NAA25
- SLC26A6
- NSFL1C
- HIP1R
- RPN1
- LSR
disease
- neoplasia
- thrombocytopenia
- coronary artery disease
regulated by
- VHL
- BCR (complex)
- Mycobacterium tuberculosis H37Rv
- Immunoglobulin
- MAP3K8
- ZC3H12A
- TP53
- CHD8
- UCHL1
- BCL6
regulates
- DVL2
- ROR1
role in cell
- generation in
- invasion by
- proliferation
- phosphorylation in
- formation
- formation in
- number
- generation
- morphology
- cell polarity formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Plasma Membrane
- secretory granule membrane
- filopodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the RHOF gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- regulation of actin cytoskeleton organization
- signal transduction
- small GTPase mediated signal transduction
- regulation of small GTPase mediated signal transduction
- actin filament organization
- cell migration
CELLULAR COMPONENT
Where in the cell the gene product is active
- secretory granule membrane
- cytoskeleton
- extracellular vesicular exosome
- cytosol
- plasma membrane
MOLECULAR FUNCTION
What the gene product does at the molecular level
- GTP binding
- protein kinase binding
- GTPase activity
- guanyl-nucleotide exchange factor activity