PDPK1 Gene Summary [Human]
Enables 3-phosphoinositide-dependent protein kinase activity; phospholipase activator activity; and phospholipase binding activity. Involved in several processes, including cell surface receptor signaling pathway; regulation of protein kinase activity; and regulation of signal transduction. Acts upstream of or within intracellular signal transduction. Located in cell projection; cytosol; and plasma membrane. Implicated in prostate cancer. Biomarker of lung non-small cell carcinoma. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | PDPK1 |
| Official Name | 3-phosphoinositide dependent protein kinase 1 [Source:HGNC Symbol;Acc:HGNC:8816] |
| Ensembl ID | ENSG00000140992 |
| Bio databases IDs | |
| Aliases | 3-phosphoinositide dependent protein kinase 1, PkB kinase |
| Synonyms | 3'-PDK, 3-phosphoinositide dependent protein kinase-1, PDK, PDK1, PDPK2, PDPK2P, PRO0461 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PDPK1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- insulin receptor binding
- Kinase regulatory loop binding domain
- ATP-binding domain
- phosphatidylinositol-3-phosphate binding domain
- PIF binding pocket
- Protein kinase domain
- proline rich domain
- phospholipase activator
- activation loop
- phosphate groove
- protein kinase binding
- nuclear export signal
- catalytic domain
- enzyme binding
- protein binding
- Pleckstrin homology-like domain
- phosphorylation site
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- 3-phosphoinositide-dependent protein kinase
- Protein Kinases, catalytic domain
- hydrophobic groove
- tyrosine phosphorylation site
Pathways
Biological processes and signaling networks where the PDPK1 gene in human plays a role, providing insight into its function and relevance in health or disease.
- Docosahexaenoic Acid (DHA) Signaling
- EIF2 Signaling
- Endometrial Cancer Signaling
- eNOS Signaling
- ErbB Signaling
- ErbB2-ErbB3 Signaling
- ErbB4 Signaling
- Fc Epsilon RI Signaling
- G Beta Gamma Signaling
- Germ Cell-Sertoli Cell Junction Signaling
- Growth Hormone Signaling
- IGF-1 Signaling
- IL-7 Signaling Pathway
- Lymphotoxin β Receptor Signaling
- Neurotrophin/TRK Signaling
- NGF Signaling
- Non-Small Cell Lung Cancer Signaling
- Prostate Cancer Signaling
- PTEN Signaling
- Telomerase Signaling
- Type II Diabetes Mellitus Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- heart failure
- acute myeloid leukemia
- motor dysfunction
- neoplasia
- cancer
- bleeding
- arterial thrombosis
- self-abusive behavior
- mild thrombocytopenia
- hyperinsulinism
role in cell
- binding
- expression in
- autophagy in
- adhesion
- differentiation
- production in
- phosphorylation in
- apoptosis
- activation in
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- apical compartment
- perinuclear region
- cellular membrane
- Nucleus
- Plasma Membrane
- endosomes
- cytosol
- cytoplasmic face of plasma membrane
- apical membrane
- recycling endosomes
- cytoplasmic vesicles
- apical vesicles
- membrane rafts
- detergent insoluble microdomains
- brush border
- cellular protrusions
- perikaryon
- postsynaptic density
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PDPK1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- insulin receptor signaling pathway
- epidermal growth factor receptor signaling pathway
- extrinsic apoptotic signaling pathway
- protein autophosphorylation
- regulation of I-kappaB kinase/NF-kappaB cascade
- protein phosphorylation
- negative regulation of protein kinase activity
- positive regulation of angiogenesis
- regulation of mast cell degranulation
- cellular response to insulin stimulus
- positive regulation of phospholipase activity
- negative regulation of endothelial cell apoptotic process
- calcium-mediated signaling
- cell migration
- intracellular signal transduction
- activation of protein kinase B activity
- T cell costimulation
- negative regulation of toll-like receptor signaling pathway
- insulin-like growth factor receptor signaling pathway
- positive regulation of release of sequestered calcium ion into cytosol
- hyperosmotic response
- positive regulation of blood vessel endothelial cell migration
- type B pancreatic cell development
- cellular response to epidermal growth factor stimulus
- negative regulation of cardiac muscle cell apoptotic process
- peptidyl-serine phosphorylation
- actin cytoskeleton organization
- negative regulation of transforming growth factor beta receptor signaling pathway
- positive regulation of protein kinase B signaling cascade
- peptidyl-threonine phosphorylation
Cellular Component
Where in the cell the gene product is active
- postsynaptic density
- nucleus
- focal adhesion
- cytoplasm
- membrane
- cytoplasmic vesicle
- cytosol
- cell projection
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- phospholipase binding
- protein serine/threonine kinase activity
- phospholipase activator activity
- 3-phosphoinositide-dependent protein kinase activity