ARHGEF19
ARHGEF19 Gene Summary
Guanine nucleotide exchange factors (GEFs) such as ARHGEF19 accelerate the GTPase activity of Rho GTPases (see RHOA, MIM 165390).[supplied by OMIM, Dec 2008]
Details
| Type | Processed Transcript |
| Official Symbol | ARHGEF19 |
| Official Name | Rho guanine nucleotide exchange factor 19 [Source:HGNC Symbol;Acc:HGNC:26604] |
| Ensembl ID | ENSG00000142632 |
| Bio databases IDs | |
| Aliases | Rho guanine nucleotide exchange factor 19, ephexin2 |
| Synonyms | 6030432F23,6430573B13Rik,DKFZP586P2321,Rho guanine nucleotide exchange factor 19,WGEF |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RhoGEF
- guanyl-nucleotide exchange factor
- PH domain
- protein binding
- Pleckstrin homology-like domain
- zDHHC ankyrin repeat binding domain
- RhoGEF domain
- Src Homology 3 domain superfamily
Pathways
Biological processes and signaling networks where the ARHGEF19 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- NES
- SRFBP1
- SMNDC1
- HMGN1
- C9orf78
- NUP35
- HP1BP3
- MBD3
- POLR2D
- NUP98
disease
- preeclampsia
- nonalcoholic fatty liver disease
- infection by HIV-1
regulated by
- cisplatin
- TGFB1
- HNF4A
- rifampin
- HMOX2
- dexamethasone
- WNT3A
- MEF2A
- troglitazone
- levodopa
regulates
- GTPase
role in cell
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the ARHGEF19 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- wound healing
- regulation of actin cytoskeleton organization
- regulation of small GTPase mediated signal transduction
- Wnt receptor signaling pathway, planar cell polarity pathway
CELLULAR COMPONENT
Where in the cell the gene product is active
- cytosol
MOLECULAR FUNCTION
What the gene product does at the molecular level
- protein binding
- GTPase activator activity
- guanyl-nucleotide exchange factor activity