PIP5K1A
PIP5K1A Gene Summary
Enables 1-phosphatidylinositol-4-phosphate 5-kinase activity and kinase binding activity. Involved in several processes, including activation of GTPase activity; focal adhesion assembly; and ruffle assembly. Located in several cellular components, including lamellipodium; nuclear speck; and ruffle membrane. Colocalizes with mRNA cleavage and polyadenylation specificity factor complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | PIP5K1A |
| Official Name | phosphatidylinositol-4-phosphate 5-kinase type 1 alpha [Source:HGNC Symbol;Acc:HGNC:8994] |
| Ensembl ID | ENSG00000143398 |
| Bio databases IDs | |
| Aliases | phosphatidylinositol-4-phosphate 5-kinase type 1 alpha |
| Synonyms | phosphatidylinositol-4-phosphate 5-kinase type 1 alpha,phosphatidylinositol-4-phosphate 5-kinase, type 1 alpha,phosphatidylinositol-4-phosphate 5-kinase, type 1, alpha,phosphatidylinositol-4-phosphate 5-kinase type 1 α,phosphatidylinositol-4-phosphate 5-kinase, type 1 α,phosphatidylinositol-4-phosphate 5-kinase, type 1, α,Pi4p5k-i,PI4P5K-I[a],Pi4p5kib,PI4P5 Kinase Alpha,PI4P5 Kinase α,PIP5K1-alpha,Pip5k1b,PIP5K1-α,PIP5K alpha,PIP5KI alpha,PIP5KI α,PIP5K α,Pipk5a,PIPKI alpha,PIPKI α,PTDINS4P 5-KINASE alpha,PTDINS4P 5-KINASE α,type I alpha PIP KINASE,type I PIPK alpha,type I PIPK α,type I α PIP KINASE |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Phosphatidylinositol phosphate kinase (PIPK) catalytic domain family
- lipid kinase
- dimerization domain
- kinase binding
- alcohol group acceptor phosphotransferase
- Phosphatidylinositol-4-phosphate 5-Kinase
- protein binding
- 1-phosphatidylinositol-3-phosphate 5-kinase
- 1-phosphatidylinositol-4-phosphate 5-kinase
Pathways
Biological processes and signaling networks where the PIP5K1A gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- EGFR
- STAG2
- DNAJC5
- ZNF467
- VPR
- CABLES2
- HEXIM1
- FLNC
- CAPN2
- ZNF653
disease
- neoplasia
- non-small cell lung cancer
- asthenozoospermia
- autosomal dominant intellectual developmental disorder with seizures type 60
- oligozoospermia
- pulmonary tuberculosis
- infection by Dengue virus 2
regulated by
- ARF6
- black raspberry extract
- progesterone
- ETV1
- EWSR1
- monocyte-derived macrophages
- n-nitrosomethylbenzylamine
- PLG
- AJUBA
- ARF1
regulates
- Ca2+
- AKT
- IL2
- YAP1
- CXCL8
- phosphatidylinositol
- BCR (complex)
- RAC1
- PIP5KL1
- phosphatidylinositol 4,5-bisphosphate
role in cell
- formation
- expression in
- migration
- chemotaxis
- assembly
- differentiation
- apoptosis
- invasion
- abnormal morphology
- invasiveness
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell surface
- Nucleus
- vacuole
- Plasma Membrane
- granules
- cytosol
- basolateral cell surfaces
- membrane ruffles
- Golgi stacks
- nucleoplasm
- nuclear speckles
- lamellipodia
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the PIP5K1A gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- signal transduction
- phospholipid biosynthetic process
- phosphatidylinositol phosphorylation
- glycerophospholipid metabolic process
- phosphatidylinositol biosynthetic process
- cell chemotaxis
- keratinocyte differentiation
- regulation of protein kinase B signaling cascade
- ruffle assembly
- phagocytosis
- focal adhesion assembly
- fibroblast migration
- actin cytoskeleton organization
- cell migration
- protein localization in plasma membrane
CELLULAR COMPONENT
Where in the cell the gene product is active
- nucleus
- focal adhesion
- mRNA cleavage and polyadenylation specificity factor complex
- nuclear speck
- ruffle membrane
- cytosol
- plasma membrane
- lamellipodium
- nucleoplasm
MOLECULAR FUNCTION
What the gene product does at the molecular level
- phosphatidylinositol kinase activity
- ATP binding
- 1-phosphatidylinositol-3-phosphate 5-kinase activity
- protein binding
- 1-phosphatidylinositol-4-phosphate 5-kinase activity
- 1-phosphatidylinositol-5-kinase activity
- kinase binding