RHOB
RHOB Gene Summary
Predicted to enable GTP binding activity; GTPase activity; and protein kinase binding activity. Involved in several processes, including cellular response to hydrogen peroxide; cellular response to ionizing radiation; and regulation of cell migration. Located in cleavage furrow and endosome membrane. Biomarker of breast cancer. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | RHOB |
| Official Name | ras homolog family member B [Source:HGNC Symbol;Acc:HGNC:668] |
| Ensembl ID | ENSG00000143878 |
| Bio databases IDs | |
| Aliases | ras homolog family member B, oncogene RHO H6 |
| Synonyms | AA017882,ARH6,ARHB,MST081,MSTP081,ras homolog family member B,Ras homolog gene family, member ab,RAS HOMOLOG GENE family, member B,ras-related homolog B,RHOH6,SEQUENCE 12 FROM PATENT WO9954460 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Small GTPase of the Ras superfamily (ill-defined subfamily)
- Ras family
- GTPase
- enzyme
- protein binding
- Ras subfamily of RAS small GTPases
- GTP binding
- small GTP-binding protein domain
- GTPase domain
- GDP binding
- Rab subfamily of small GTPases
- Ras of Complex, Roc, domain of DAPkinase
- Rho (Ras homology) subfamily of Ras-like small GTPases
- P-loop containing Nucleoside Triphosphate Hydrolases
Pathways
Biological processes and signaling networks where the RHOB gene plays a role, providing insight into its function and relevance in health or disease.
- Actin Nucleation by ARP-WASP Complex
- Cholecystokinin/Gastrin-mediated Signaling
- CXCR4 Signaling
- Germ Cell-Sertoli Cell Junction Signaling
- Glioblastoma Multiforme Signaling
- Glioma Invasiveness Signaling
- Gαq Signaling
- HMGB1 Signaling
- IL-8 Signaling
- ILK Signaling
- Integrin Signaling
- mTOR Signaling
- Production of Nitric Oxide and Reactive Oxygen Species in Macrophages
- Regulation of Actin-based Motility by Rho
- RhoGDI Signaling
- Semaphorin Signaling in Neurons
- Serotonin Receptor Signaling
- Sphingosine-1-phosphate Signaling
- Tec Kinase Signaling
- Thrombin Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- SLC11A2
- CD44
- SLC7A1
- TIAM1
- CTNNB1
- PKN1
- RAB32
- UBIAD1
- ECT2
- CC2D1A
disease
- neoplasia
- metastasis
- epithelial cancer
- breast cancer
- tumorigenesis
- amyotrophic lateral sclerosis
- spontaneous abortion
- T acute lymphoblastic leukemia
- primary myelofibrosis
- neoplastic cell transformation
regulated by
- SLC40A1
- IL1B
- L-methionine
- mir-21 (includes others)
- TGFB1
- EGFR
- TNF
- MR-409
- RHOA
- lipopolysaccharide
regulates
- AKT
- GSK3B
- PTGS2
- NFkB (complex)
- TNF
- CXCL8
- Ap1
- MMP2
- CASP3
- JNK
role in cell
- phosphorylation in
- accumulation
- accumulation in
- activation
- cell death
- activation in
- apoptosis
- expression in
- cell rounding
- recruitment
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- myelin enriched fraction
- membrane fraction
- intracellular compartment
- intracellular space
- perinuclear region
- postsynaptic region
- cellular membrane
- Nucleus
- Plasma Membrane
- endosomes
- lysosome
- Golgi Apparatus
- granules
- cytosol
- vesicle membrane
- endosomal compartment
- endosomal membrane
- nuclear rim
- nuclear envelope
- synaptic vesicles
- neurites
- synapse
- early endosomes
- late endosomes
- multivesicular bodies
- cleavage furrow
- perikaryon
- presynaptic terminals
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the RHOB gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- signal transduction
- endothelial tube morphogenesis
- negative regulation of cell cycle
- actin filament organization
- cell adhesion
- endosome to lysosome transport
- Rho protein signal transduction
- intracellular protein transport
- positive regulation of angiogenesis
- angiogenesis
- cytokinesis after mitosis
- apoptotic process
- positive regulation of apoptotic process
- cell differentiation
- cellular response to ionizing radiation
- cellular response to hydrogen peroxide
- regulation of cell migration
- positive regulation of endothelial cell migration
- negative regulation of cell migration
CELLULAR COMPONENT
Where in the cell the gene product is active
- late endosome membrane
- nucleus
- early endosome
- extracellular vesicular exosome
- focal adhesion
- cleavage furrow
- cytosol
- endosome membrane
- plasma membrane
MOLECULAR FUNCTION
What the gene product does at the molecular level
- GTP binding
- protein binding
- GTPase activity
- GDP binding